Senders Max L, Calcagno Claudia, Tawakol Ahmed, Nahrendorf Matthias, Mulder Willem J M, Fayad Zahi A
BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Nat Biomed Eng. 2023 Mar;7(3):202-220. doi: 10.1038/s41551-022-00970-7. Epub 2022 Dec 15.
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact the haematopoietic system, which through immunity and inflammation may aggravate pre-existing atherosclerosis. The interplay between the haematopoietic system and its modulation of atherosclerosis has been studied by imaging the cardiovascular system and the activation of haematopoietic organs via scanners integrating positron emission tomography and resonance imaging (PET/MRI). In this Perspective, we review the applicability of integrated whole-body PET/MRI for the study of immune-mediated phenomena associated with haematopoietic activity and cardiovascular disease, and discuss the translational opportunities and challenges of the technology.
心肌梗死、中风、精神障碍、神经退行性病变、自身免疫性疾病、癌症以及人类免疫缺陷病毒会影响造血系统，而造血系统通过免疫和炎症反应可能会加重已有的动脉粥样硬化。通过将正电子发射断层扫描和磁共振成像相结合的扫描仪（PET/MRI）对心血管系统进行成像以及对造血器官的激活情况进行成像，人们已经对造血系统及其对动脉粥样硬化的调节之间的相互作用进行了研究。在这篇观点文章中，我们综述了全身PET/MRI整合技术在研究与造血活动及心血管疾病相关的免疫介导现象方面的适用性，并讨论了该技术的转化机遇和挑战。
