Yang Hui, Wuren Tana, Zhai Bin-Tao, Liu Yang, Er Demtu
College of Basic Medical Science Qinghai University Xining Qinghai PR China.
Research Center for High Altitude Medicine Qinghai University Xining Qinghai PR China.
Food Sci Nutr. 2024 Aug 21;12(10):7048-7059. doi: 10.1002/fsn3.4323. eCollection 2024 Oct.
Milk-derived exosomes (MDEs), being a component of milk, have the potential to support immune system maturation in offspring and enhance immune cell proliferation. Through the transport and transmission of essential signaling molecules, MDEs contribute to the regulation of intergenerational and intraspecies communication, thereby impacting nutrient uptake and metabolic functions. A comprehensive comprehension of MDE functionalities is imperative for enhancing the quality of the dairy industry. A systematic search of the databases PubMed/Medline, Web of Science, and Scopus utilizing predetermined keywords resulted in the identification of 418 articles, of which 67 were chosen for inclusion in this review, which specifically explores the intersection of immune response and nutrition. This article provides a critical analysis of the classification of extracellular vesicles, the mechanisms underlying the biosynthesis of microvesicular dietary exosomes (MDEs), the components of MDEs, and their relevance in the contexts of nutrition and immune modulation. The primary aim of this review was to offer valuable scholarly insights to support the advancement and practical application of MDEs.
乳源外泌体（MDEs）作为乳汁的一个组成部分，有潜力支持后代免疫系统成熟并增强免疫细胞增殖。通过运输和传递重要的信号分子，MDEs有助于调节代际和种内通讯，从而影响营养物质摄取和代谢功能。全面了解MDEs的功能对于提高乳制品行业质量至关重要。利用预先确定的关键词对PubMed/Medline、Web of Science和Scopus数据库进行系统检索，共识别出418篇文章，其中67篇被选入本综述，该综述专门探讨免疫反应与营养的交叉点。本文对细胞外囊泡的分类、微泡性膳食外泌体（MDEs）生物合成的潜在机制、MDEs的成分及其在营养和免疫调节方面的相关性进行了批判性分析。本综述的主要目的是提供有价值的学术见解，以支持MDEs的发展和实际应用。
