Odunitan Tope T, Apanisile Boluwatife T, Afolabi Justinah A, Adeniwura Praise O, Akinboade Modinat W, Ibrahim Najahtulahi O, Alare Kehinde P, Saibu Oluwatosin A, Adeosun Oyindamola A, Opeyemi Hammed S, Ayiti Kolawole S
Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria.
Genomics Unit, Helix Biogen Institute, Ogbomosho, Nigeria.
Chem Biodivers. 2025 Mar;22(3):e202401349. doi: 10.1002/cbdv.202401349. Epub 2024 Dec 4.
In the fight against pathogenic infections, antimicrobial peptides (AMPs) constitute a novel and promising class of compounds that defies accepted drug development conventions like Lipinski's rule. AMPs are remarkably effective against a variety of pathogens, including viruses, bacteria, parasites, and fungi. Their effectiveness, despite differing from traditional drug-like properties defies accepted standards. This review investigates the complex world of AMPs with an emphasis on their structural and physicochemical properties, which include size, sequence, structure, charge, and half-life. These distinguishing characteristics set AMPs apart from conventional therapeutics that adhere to Lipinski's rules and greatly contribute to their selective targeting, reduction of resistance, multifunctionality, and broad-spectrum efficacy. In contrast to traditional drugs that follow Lipinski's guidelines, AMPs have special qualities that play a big role in their ability to target specific targets, lower resistance, and work across a wide range of conditions. Our work is unique because of this nuanced investigation, which offers a new viewpoint on the potential of AMPs in tackling the worldwide problem of antibiotic resistance. In the face of the escalating global challenge of antibiotic resistance, antimicrobial peptides (AMPs) are innovative antimicrobial agents with unique mechanisms of action that challenge traditional Lipinski's Rule. They can withstand various microbial threats through membrane disruption, intracellular targeting, and immunomodulation. AMP versatility sets them apart from other antibiotics and their potential to address microbial infections and antibiotic resistance is growing. To fully unlock their potential, traditional drug development approaches need to be reconsidered. AMPs have revolutionary potential, paving the way for innovative solutions to health issues and transforming the antimicrobial therapy landscape.
在对抗病原体感染的斗争中，抗菌肽（AMPs）构成了一类新颖且有前景的化合物，它们突破了诸如Lipinski规则等公认的药物开发常规。抗菌肽对多种病原体具有显著效果，包括病毒、细菌、寄生虫和真菌。尽管其有效性与传统类药物特性不同，却突破了公认标准。本综述研究了抗菌肽的复杂世界，重点关注其结构和物理化学性质，包括大小、序列、结构、电荷和半衰期。这些独特特性使抗菌肽有别于遵循Lipinski规则的传统疗法，并极大地促成了它们的选择性靶向、耐药性降低、多功能性和广谱疗效。与遵循Lipinski准则的传统药物相比，抗菌肽具有特殊性质，在其靶向特定靶点、降低耐药性以及在广泛条件下起作用的能力方面发挥着重要作用。我们的工作因其细致入微的研究而独具特色，这为抗菌肽在应对全球抗生素耐药性问题方面的潜力提供了新视角。面对全球抗生素耐药性挑战的不断升级，抗菌肽是具有独特作用机制的创新抗菌剂，对传统的Lipinski规则构成挑战。它们可通过膜破坏、细胞内靶向和免疫调节来抵御各种微生物威胁。抗菌肽的多功能性使其有别于其他抗生素，其解决微生物感染和抗生素耐药性问题的潜力也在不断增长。为充分释放其潜力，需要重新考虑传统的药物开发方法。抗菌肽具有革命性潜力，为健康问题的创新解决方案铺平道路，并改变抗菌治疗格局。
