• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Leptin signaling maintains autonomic stability during severe influenza infection in mice.

作者信息

Muñoz-Rojas Andrés R, Wang Adam C, Pomeranz Lisa E, Reizis Elizabeth L, Stout-Delgado Heather W, Miranda Ileana C, Rajagopalan Krishnan, Gwatiringa Tadiwanashe, Fan Roger R, Huda Ahmad A, Maskey Neha, Olumuyide Roseline P, Patel Aryan S, Friedman Jeffrey M, Mathis Diane, Rajagopalan Kartik N

机构信息

Department of Immunology, Harvard Medical School, Boston, Massachusetts, USA.

Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.

出版信息

J Clin Invest. 2024 Oct 31;135(1):e182550. doi: 10.1172/JCI182550.

DOI:10.1172/JCI182550
PMID:39480494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11684820/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b5/11684820/79aa61455931/jci-135-182550-g153.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b5/11684820/79aa61455931/jci-135-182550-g153.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b5/11684820/79aa61455931/jci-135-182550-g153.jpg

相似文献

1
Leptin signaling maintains autonomic stability during severe influenza infection in mice.瘦素信号通路在小鼠严重流感感染期间维持自主神经稳定性。
J Clin Invest. 2024 Oct 31;135(1):e182550. doi: 10.1172/JCI182550.
2
Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages.肥胖的、瘦素受体缺陷小鼠甲型流感病毒清除受损与肺上皮细胞和巨噬细胞中的瘦素信号无关。
PLoS One. 2014 Sep 18;9(9):e108138. doi: 10.1371/journal.pone.0108138. eCollection 2014.
3
Leptin mediates the pathogenesis of severe 2009 pandemic influenza A(H1N1) infection associated with cytokine dysregulation in mice with diet-induced obesity.瘦素介导了饮食诱导肥胖小鼠中细胞因子失调相关的 2009 年大流行甲型 H1N1 流感重症感染的发病机制。
J Infect Dis. 2013 Apr 15;207(8):1270-80. doi: 10.1093/infdis/jit031. Epub 2013 Jan 16.
4
Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.下丘脑的瘦素受体信号传导通过磷脂酰肌醇3激酶和AMP激活的蛋白激酶调节肝脏自主神经活动。
J Neurosci. 2015 Jan 14;35(2):474-84. doi: 10.1523/JNEUROSCI.1828-14.2015.
5
Obesity and respiratory infections: does excess adiposity weigh down host defense?肥胖与呼吸道感染：过多的体脂是否会削弱宿主防御？
Pulm Pharmacol Ther. 2013 Aug;26(4):412-9. doi: 10.1016/j.pupt.2012.04.006. Epub 2012 May 24.
6
Leptin and its Relation to Autonomic Activity, Endothelial Cell Activation and Blood Pressure in a Young Black and White Population: The African-PREDICT study.瘦素及其与年轻黑人和白人人群自主神经活动、内皮细胞活化及血压的关系：非洲预测研究
Horm Metab Res. 2018 Mar;50(3):257-266. doi: 10.1055/s-0043-122236. Epub 2017 Nov 27.
7
Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?肥胖与病毒感染易感性及严重程度：从流感到 COVID-19 的启示。瘦素是否发挥作用？
Int J Mol Sci. 2021 Mar 20;22(6):3183. doi: 10.3390/ijms22063183.
8
Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin.瘦素调节区域性自主神经活动中 POMC 和 AgRP 神经元的差异贡献。
Mol Metab. 2018 Feb;8:1-12. doi: 10.1016/j.molmet.2017.12.006. Epub 2017 Dec 18.
9
Immunity to influenza: Impact of obesity.流感免疫：肥胖的影响。
Obes Res Clin Pract. 2019 Sep-Oct;13(5):419-429. doi: 10.1016/j.orcp.2019.05.003. Epub 2019 Sep 19.
10
Leptin and leptin-related gene polymorphisms, obesity, and influenza A/H1N1 vaccine-induced immune responses in older individuals.瘦素和瘦素相关基因多态性、肥胖与老年人甲型 H1N1 流感疫苗免疫应答的关系。
Vaccine. 2014 Feb 7;32(7):881-7. doi: 10.1016/j.vaccine.2013.12.009. Epub 2013 Dec 18.

本文引用的文献

1
Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin.瘦素调节区域性自主神经活动中 POMC 和 AgRP 神经元的差异贡献。
Mol Metab. 2018 Feb;8:1-12. doi: 10.1016/j.molmet.2017.12.006. Epub 2017 Dec 18.
2
Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice.肥胖增加小鼠感染大流行H1N1流感病毒期间的死亡率并调节肺代谢组。
J Immunol. 2015 May 15;194(10):4846-59. doi: 10.4049/jimmunol.1402295. Epub 2015 Apr 10.