脂肪来源的间充质干细胞分泌组通过激活Nrf2减轻朊病毒蛋白肽（106-126）诱导的氧化应激。 - Suppr

Adipose-Derived Mesenchymal Stem Cell Secretome Attenuates Prion Protein Peptide (106-126)-Induced Oxidative Stress via Nrf2 Activation.

作者信息

Zayed Mohammed, Jeong Byung-Hoon

机构信息

Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, 54531, Republic of Korea.

Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju, 54896, Republic of Korea.

出版信息

Stem Cell Rev Rep. 2025 Feb;21(2):589-592. doi: 10.1007/s12015-024-10811-6. Epub 2024 Oct 31.

DOI:10.1007/s12015-024-10811-6

PMID:39480613

Abstract

摘要

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Adipose-Derived Mesenchymal Stem Cell Secretome Attenuates Prion Protein Peptide (106-126)-Induced Oxidative Stress via Nrf2 Activation.脂肪来源的间充质干细胞分泌组通过激活Nrf2减轻朊病毒蛋白肽（106-126）诱导的氧化应激。

Stem Cell Rev Rep. 2025 Feb;21(2):589-592. doi: 10.1007/s12015-024-10811-6. Epub 2024 Oct 31.

Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options.鼻腔间充质干细胞 secretome 给药显著抑制酒精和尼古丁的自我给药，并阻断复吸：机制和转化选择。

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Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stem Cells Alleviate Apoptosis and Oxidative Stress of Retinal Pigment Epithelial Cells Through Activation of Nrf2 Signaling Pathway.脂肪来源间充质干细胞衍生的细胞外囊泡通过激活Nrf2信号通路减轻视网膜色素上皮细胞的凋亡和氧化应激。

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Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins.脂肪间充质干细胞的细胞外囊泡通过细胞外囊泡货物和可溶性蛋白的协同作用促进骨骼肌再生。

Stem Cell Res Ther. 2019 Apr 5;10(1):116. doi: 10.1186/s13287-019-1213-1.

Downregulation of Nrf2 promotes autophagy-dependent osteoblastic differentiation of adipose-derived mesenchymal stem cells.Nrf2的下调促进脂肪来源间充质干细胞的自噬依赖性成骨分化。

Exp Cell Res. 2016 Dec 10;349(2):221-229. doi: 10.1016/j.yexcr.2016.09.013. Epub 2016 Sep 23.

Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia.鼻腔内给予间充质干细胞 secretome 可减少海马区氧化应激、神经炎症和细胞死亡，改善围产期窒息后的行为学结局。

Int J Mol Sci. 2020 Oct 21;21(20):7800. doi: 10.3390/ijms21207800.

The secretome of adipose-derived mesenchymal stem cells attenuates epithelial-mesenchymal transition in human corneal epithelium.脂肪来源间充质干细胞的分泌组可减弱人角膜上皮中的上皮-间质转化。

Regen Ther. 2019 Jul 2;11:114-122. doi: 10.1016/j.reth.2019.06.005. eCollection 2019 Dec.

Mesenchymal stem cell secretome protects against oxidative stress-induced ocular blast visual pathologies.间充质干细胞 secretome 可预防氧化应激诱导的眼冲击视觉病变。

Exp Eye Res. 2022 Feb;215:108930. doi: 10.1016/j.exer.2022.108930. Epub 2022 Jan 10.

The Mitochondrial-Derived Peptide MOTS-c Attenuates Oxidative Stress Injury and the Inflammatory Response of H9c2 Cells Through the Nrf2/ARE and NF-κB Pathways.线粒体衍生肽 MOTS-c 通过 Nrf2/ARE 和 NF-κB 通路减轻 H9c2 细胞的氧化应激损伤和炎症反应。

Cardiovasc Eng Technol. 2022 Oct;13(5):651-661. doi: 10.1007/s13239-021-00589-w. Epub 2021 Dec 2.

Protective Effects of Adipose Mesenchymal Stem Cell Secretome On Oxidative Stress-Induced Bisphenol-A in Isolated Rat Testes Mitochondria and Sperm Quality.脂肪间充质干细胞分泌组对氧化应激诱导的大鼠离体睾丸线粒体双酚A及精子质量的保护作用

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Mesenchymal stem cell-derived exosomes as a potential therapeutic strategy for ferroptosis.间充质干细胞衍生的外泌体作为铁死亡的一种潜在治疗策略。

Stem Cell Res Ther. 2025 Jul 15;16(1):368. doi: 10.1186/s13287-025-04511-2.

Mesenchymal Stem Cell Secretome Attenuates PrP-Induced Neurotoxicity by Suppressing Neuroinflammation and Apoptosis and Enhances Cell Migration.间充质干细胞分泌组通过抑制神经炎症和细胞凋亡减轻朊蛋白诱导的神经毒性并增强细胞迁移。

Cells. 2025 Jun 5;14(11):851. doi: 10.3390/cells14110851.

Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease.脂肪间充质干细胞联合类淋巴系统激活在朊病毒病中的治疗作用

Mol Neurodegener. 2025 Apr 17;20(1):42. doi: 10.1186/s13024-025-00835-y.

Biological characteristics and transcriptomic profile of adipose-derived mesenchymal stem cells isolated from prion-infected murine model.从朊病毒感染小鼠模型中分离的脂肪来源间充质干细胞的生物学特性和转录组概况

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本文引用的文献

Oxidative and Inflammatory Events in Prion Diseases: Can They Be Therapeutic Targets?朊病毒疾病中的氧化和炎症事件：它们能否成为治疗靶点？

Curr Aging Sci. 2019;11(4):216-225. doi: 10.2174/1874609812666190111100205.

Review: PrP 106-126 - 25 years after.综述：朊蛋白 106-126 - 25 年之后。

Neuropathol Appl Neurobiol. 2019 Aug;45(5):430-440. doi: 10.1111/nan.12538. Epub 2019 Feb 3.

The Neuroprotective Effect of Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells is Impaired by N-acetyl Cysteine Supplementation.人脂肪间充质干细胞条件培养液的神经保护作用被 N-乙酰半胱氨酸补充剂削弱。

Mol Neurobiol. 2018 Jan;55(1):13-25. doi: 10.1007/s12035-017-0714-0.

Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt-Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress.散发性 Creutzfeldt-Jakob 病亚型小脑的分子改变，DJ-1 作为氧化应激的关键调节剂。

Mol Neurobiol. 2018 Jan;55(1):517-537. doi: 10.1007/s12035-016-0294-4. Epub 2016 Dec 14.

Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?旁分泌效应对再生医学中干细胞治疗的关键作用：我们能否将干细胞分泌的旁分泌因子和微囊泡转化为更好的治疗策略？

Leukemia. 2012 Jun;26(6):1166-73. doi: 10.1038/leu.2011.389. Epub 2011 Dec 19.

The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress.Nrf2-抗氧化反应元件信号通路及其由氧化应激激活的过程。

J Biol Chem. 2009 May 15;284(20):13291-5. doi: 10.1074/jbc.R900010200. Epub 2009 Jan 30.

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Adipose-Derived Mesenchymal Stem Cell Secretome Attenuates Prion Protein Peptide (106-126)-Induced Oxidative Stress via Nrf2 Activation.

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