Department of Endocrinology-Diabetology-Nutrition, Mohammed VI University Hospital, Medical School, Mohamed the First University, Oujda, Morocco.
Laboratory of Epidemiology, Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, Mohamed the First University, Oujda, Morocco.
Gynecol Endocrinol. 2024 Dec;40(1):2381501. doi: 10.1080/09513590.2024.2381501. Epub 2024 Oct 31.
Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women of reproductive age. The current study sought to assess vitamin D status in women with PCOS compared to the control group and to describe the association between vitamin D deficiency and the features of PCOS.
A descriptive retrospective study about 176 women of reproductive age was conducted. The sample was divided into two groups: individuals with PCOS (82 women) and healthy individuals without PCOS (94 women). Vitamin D deficiency was defined as a serum concentration less than 10 ng/ml. We used the Statistical Package for the Social Sciences (SPSS), version 21 for all analyses.
In our study, vitamin D deficiency was observed in 40.2% PCOS patients and 24% controls. The 25(OH)D level was lower in PCOS women and the incidence of vitamin D deficiency and insufficiency were significantly higher in comparison with the control group ( < 0.05). Furthermore, PCOS women with insulin resistance or obesity had lower 25(OH)D levels in comparison with PCOS individuals without IR or obesity. Furthermore, a significant correlation was found between homeostatic model assessment for insulin resistance (HOMA-IR)/body mass index (BMI) and vitamin D status.
Vitamin D deficiency could be one of the etiological mechanisms of PCOS. In fact, the prevalence of vitamin D deficiency in PCOS women is evident, principally in those with obesity or IR. Also, the serum 25(OH)D level was correlated with parameters of insulin resistance and metabolic syndrome. Therefore, it is proposed that vitamin D supplementation may be beneficial for the management of PCOS patients.
多囊卵巢综合征（PCOS）是育龄妇女常见的激素紊乱疾病。本研究旨在评估多囊卵巢综合征患者与对照组妇女的维生素 D 状况，并描述维生素 D 缺乏与 PCOS 特征之间的关系。
进行了一项关于 176 名育龄妇女的描述性回顾性研究。该样本分为两组：多囊卵巢综合征患者（82 名）和无多囊卵巢综合征的健康个体（94 名）。维生素 D 缺乏定义为血清浓度<10ng/ml。所有分析均使用社会科学统计软件包（SPSS）版本 21。
在我们的研究中，40.2%的多囊卵巢综合征患者和 24%的对照组患者存在维生素 D 缺乏。多囊卵巢综合征妇女的 25（OH）D 水平较低，与对照组相比，维生素 D 缺乏和不足的发生率明显更高（<0.05）。此外，与无胰岛素抵抗或肥胖的多囊卵巢综合征患者相比，存在胰岛素抵抗或肥胖的多囊卵巢综合征患者的 25（OH）D 水平更低。此外，还发现稳态模型评估的胰岛素抵抗（HOMA-IR）/体重指数（BMI）与维生素 D 状态之间存在显著相关性。
维生素 D 缺乏可能是 PCOS 的病因机制之一。事实上，多囊卵巢综合征妇女维生素 D 缺乏的发生率很高，尤其是肥胖或胰岛素抵抗的妇女。此外，血清 25（OH）D 水平与胰岛素抵抗和代谢综合征的参数相关。因此，建议补充维生素 D 可能有益于多囊卵巢综合征患者的管理。
