Department of Food Science and Technology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand 248002, India.
Department of Physiotherapy, Guru Nanak Dev University, Amritsar, Punjab 143005, India.
Food Chem. 2025 Feb 1;464(Pt 2):141779. doi: 10.1016/j.foodchem.2024.141779. Epub 2024 Oct 28.
Phytoestrogens, derived from plants possesses structural similarity with 17 β-estradiol found in mammals. It is abundantly present in soybean along with red clove, alfalfa as well as other legumes, nuts, vegetables and seeds. It is used as hormone replacement therapy and exhibits both anti-estrogenic and estrogenic properties that linked to therapeutic benefits as well as plays active role in sports nutrition. Despite the potential benefits of phytoestrogens, their low solubility, bioavailability, and stability make it challenging to target them effectively. Recent advancements in nanotechnology have paved in facilitating target delivery. Scaling at nano level offered greater surface area, improved solubility, and bioavailability of phytoestrogens which has ultimately reduced the required medication dosage, and enhanced cost-effectiveness, particularly for expensive bioactive substances where precise dosages are recommended. The present article discussed about the potential application of nanotechnology in enhancing therapeutic benefits of phytoestrogens while minimizing their potential side effects.
植物雌激素来源于植物，与哺乳动物中发现的 17β-雌二醇具有结构相似性。它在大豆中大量存在，同时也存在于红丁香、紫花苜蓿以及其他豆类、坚果、蔬菜和种子中。它被用作激素替代疗法，具有抗雌激素和雌激素特性，与治疗益处相关，并在运动营养中发挥积极作用。尽管植物雌激素具有潜在的益处，但它们的低溶解度、生物利用度和稳定性使得有效地针对它们成为挑战。最近纳米技术的进步为靶向输送提供了便利。纳米级别的缩放提供了更大的表面积，提高了植物雌激素的溶解度和生物利用度，最终减少了所需的药物剂量，并提高了成本效益，特别是对于需要精确剂量的昂贵生物活性物质。本文讨论了纳米技术在增强植物雌激素治疗益处的同时最小化其潜在副作用方面的潜在应用。
