Zeller W J, Berger M R, Henne T, Weber E
Cancer Res. 1986 Apr;46(4 Pt 1):1714-6.
The combination toxicity index of 1-methyl-1-nitrosourea plus 1,3-bis (2-chloroethyl)-1-nitrosourea determined in the rat was 0.32. This overadditive combination toxicity appears mainly to be due to severe damage of the intestinal mucosa as diagnosed by histological examination and to damage of pluripotent stem cells in the bone marrow as could be assessed by the spleen colony technique. The molar ratio of 1-methyl-1-nitrosourea to 1,3-bis(2-chloroethyl)-1-nitrosourea resulting in maximum mortality was about 6. Concomitantly measured DNA interstrand cross-linking in bone marrow cells revealed a slight increase in DNA interstrand cross-linking following both drugs compared to 1, 3-bis(2-chloroethyl)-1-nitrosourea alone.
在大鼠中测定的1-甲基-1-亚硝基脲加1,3-双（2-氯乙基）-1-亚硝基脲的联合毒性指数为0.32。这种超相加联合毒性主要似乎是由于组织学检查诊断出的肠黏膜严重损伤以及通过脾集落技术评估的骨髓多能干细胞损伤所致。导致最大死亡率的1-甲基-1-亚硝基脲与1,3-双（2-氯乙基）-1-亚硝基脲的摩尔比约为6。同时测量的骨髓细胞中的DNA链间交联显示，与单独使用1,3-双（2-氯乙基）-1-亚硝基脲相比，两种药物处理后DNA链间交联略有增加。
