O'Donnell J F, McKoy W S, Makuch R W, Bull J M
Cancer Res. 1979 Jul;39(7 Pt 1):2547-9.
Hyperthermia has been shown to increase the cytotoxic effect of certain cancer chemotherapeutic agents in vitro and in vivo. It is not known whether the combination of hyperthermia plus these chemotherapeutic drugs will also increase the toxicity of the drugs. This study was undertaken to evaluate the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea combined with hyperthermia on normal mouse bone marrow in vitro. An increased effect of the combination was seen when the marrow was heated at 42 degrees in the presence of the drug for 15 min (p less than 0.025) and for 1 hr (p less than 0.005). Incubations for 2 hr produced a significant decrease of control growth, such that no increased effect of the combination of drug plus hyperthermia could be seen. In order for the increased effects to be seen, heating had to be done simultaneously in the presence of the drug. Clinicians using the combination of whole-body hyperthermia plus 1,3-bis(2-chloroethyl)-1-nitrosourea should be aware of possible increased marrow toxicity.
高温已被证明在体外和体内均可增强某些癌症化疗药物的细胞毒性作用。尚不清楚高温与这些化疗药物联合使用是否也会增加药物的毒性。本研究旨在评估1,3 - 双（2 - 氯乙基）-1 - 亚硝基脲与高温联合对正常小鼠骨髓的体外毒性作用。当骨髓在药物存在下于42℃加热15分钟（p < 0.025）和1小时（p < 0.005）时，联合作用增强。孵育2小时导致对照生长显著下降，以至于无法观察到药物加高温联合的增强作用。为了观察到增强作用，必须在药物存在下同时进行加热。使用全身高温加1,3 - 双（2 - 氯乙基）-1 - 亚硝基脲联合治疗的临床医生应意识到可能增加的骨髓毒性。
