Faculty of Medicine, University of Vale do Rio dos Sinos, Rio Grande do Sul, Brazil.
Department of Software and Information Systems Engineering, Ben-Gurion University of Negev, Be'er Sheva, Israel.
Autoimmun Rev. 2024 Dec;23(12):103676. doi: 10.1016/j.autrev.2024.103676. Epub 2024 Oct 29.
Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) encompasses a spectrum of autoimmune and inflammatory conditions triggered by various adjuvants, leading to significant health challenges. This study aims to understand the research landscape and future directions of ASIA through a comprehensive bibliometric analysis.
Relevant original articles were retrieved from the Scopus database, focusing on publications from 2011 to July 2024. The analysis included evaluating countries/regions, institutions, authors, co-cited references, and keywords using VOSviewer and Biblioshiny software.
The final analysis incorporated 346 documents contributed by numerous researchers from multiple institutions worldwide. Israel emerged as the leading contributor to ASIA research. The study found that while there are significant international collaborations, certain countries like Israel and Italy play central roles in these networks. Key research areas identified include autoimmunity, adjuvants, vaccines, and silicone. Notable keywords include "ASIA syndrome," "Autoimmunity," "Adjuvants," and "Silicone." The citation analysis highlighted the impactful nature of research from Israel, Italy, and Mexico. In addition, the analysis highlights the growing body of evidence that supports the role of adjuvants in triggering autoimmune responses. Over the years, there has been a significant increase in publications investigating the mechanisms by which adjuvants (such as those used in vaccines, silicone implants, and other medical applications) can activate immune responses, leading to conditions associated with ASIA syndrome.
The field of ASIA research is experiencing rapid growth, characterized by increasing publication activity and robust international collaborations. Future research is likely to focus on the mechanisms underlying ASIA syndrome and improving patient outcomes.
佐剂诱发的自身免疫/炎症综合征（ASIA）涵盖了一系列由各种佐剂引发的自身免疫和炎症性疾病，给人们带来了重大的健康挑战。本研究旨在通过全面的文献计量分析，了解 ASIA 的研究现状和未来方向。
从 Scopus 数据库中检索到相关的原始文章，重点关注 2011 年至 2024 年 7 月期间的出版物。使用 VOSviewer 和 Biblioshiny 软件对国家/地区、机构、作者、共引参考文献和关键词进行评估。
最终分析纳入了 346 篇由来自世界各地多个机构的众多研究人员撰写的文献。以色列是 ASIA 研究的主要贡献者。研究发现，尽管存在着显著的国际合作，但某些国家（如以色列和意大利）在这些网络中发挥着核心作用。确定的主要研究领域包括自身免疫、佐剂、疫苗和硅酮。值得注意的关键词包括“ASIA 综合征”、“自身免疫”、“佐剂”和“硅酮”。引文分析突出了来自以色列、意大利和墨西哥的研究的影响力。此外，该分析还强调了越来越多的证据支持佐剂在引发自身免疫反应方面的作用。多年来，人们对佐剂（如疫苗、硅酮植入物和其他医学应用中使用的佐剂）如何激活免疫反应，导致与 ASIA 综合征相关的疾病的机制进行了大量研究。
ASIA 研究领域正在迅速发展，其特点是出版活动不断增加，国际合作日益增强。未来的研究可能集中在 ASIA 综合征的发病机制和改善患者预后方面。
