Department of Internal Medicine and Medical Specialities, Rheumatology Unit, Sapienza University of Rome, Italy; The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel.
Department of Internal Medicine and Medical Specialities, Rheumatology Unit, Sapienza University of Rome, Italy.
J Autoimmun. 2014 Jun;51:10-6. doi: 10.1016/j.jaut.2014.03.003. Epub 2014 Apr 26.
Recently, a new syndrome, namely the "Autoimmune/inflammatory syndrome induced by adjuvants" (ASIA) has been defined. In this syndrome different conditions characterized by common signs and symptoms and induced by the presence of an adjuvant are included. The adjuvant is a substance capable of boosting the immune response and of acting as a trigger in the development of autoimmune diseases. Post-vaccination autoimmune phenomena represent a major issue of ASIA. Indeed, despite vaccines represent a mainstay in the improvement of human health, several of these have been implicated as a potential trigger for autoimmune diseases. Sjogren's Syndrome (SjS) is a systemic chronic autoimmune inflammatory disease characterized by the presence of an inflammatory involvement of exocrine glands accompanied by systemic manifestations. Own to the straight association between infectious agents exposure (mainly viruses) and sicca syndrome development, the possible link between vaccine and SjS is not surprising. Indeed, a few cases of SjS following vaccine delivery have been reported. At the same extent, the induction of SjS following silicone exposure has been described too. Thus, the aim of this review was to focus on SjS and its possible development following vaccine or silicone exposure in order to define another possible facet of the ASIA syndrome.
最近，人们定义了一种新的综合征，即“佐剂诱发的自身免疫/炎症综合征”（ASIA）。该综合征包含了多种不同的病症，其特征为具有共同的症状和体征，并由佐剂的存在引起。佐剂是一种能够增强免疫反应并作为自身免疫性疾病发展触发因素的物质。疫苗接种后的自身免疫现象是 ASIA 的一个主要问题。事实上，尽管疫苗是改善人类健康的主要手段之一，但其中一些疫苗已被认为是自身免疫性疾病的潜在触发因素。干燥综合征（SjS）是一种系统性慢性自身免疫性炎症性疾病，其特征是外分泌腺的炎症性受累伴有全身表现。由于传染性病原体暴露（主要是病毒）与干燥综合征的发展之间存在直接关联，因此疫苗与 SjS 之间的可能联系并不令人惊讶。事实上，已经报道了几例接种疫苗后出现 SjS 的病例。同样，硅酮暴露后也会诱发 SjS。因此，本综述的目的是重点关注 SjS 及其在疫苗或硅酮暴露后的可能发展，以确定 ASIA 综合征的另一个可能方面。
