Khobragade Pranali Y, Petrosyan Sarah, Dey Sharmistha, Dey A B, Lee Jinkook
Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
J Am Geriatr Soc. 2025 Mar;73(3):685-696. doi: 10.1111/jgs.19252. Epub 2024 Oct 31.
The rising burden of dementia calls for high-quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI-DAD) was designed to provide longitudinal assessments of cognition and dementia in India. All Wave 1 participants were recruited for a follow-up interview, and a refresher sample was drawn from the Longitudinal Aging Study in India, a nationally representative cohort of Indians aged 45 and older. Respondents underwent a battery of cognitive tests, geriatric assessments, and venous blood collection. Their health and cognitive status were also assessed through an interview with a close family member or friend. Clinical consensus diagnosis was made based on the Clinical Dementia Rating®, and comprehensive data on risk factors of dementia were collected, including neurodegenerative biomarkers, sensory function, and environmental exposures. A total of 4635 participants were recruited between 2022 and 2024 from 22 states and union territories of India, accounting for 97.9% of the population in India. The response rate was 84.0%, and 71.5% of the participants provided venous blood specimen. LASI-DAD provides rich new data to study cognition, dementia, and their risk factors longitudinally in a nationally representative sample of older adults in India. Longitudinal cognitive data, together with longitudinally assessed biomarker data and novel data on sensory function and environmental exposures, provide a unique opportunity to establish associations between risk factors and biologically defined cognitive aging phenotypes.
痴呆症负担的不断增加需要有关认知衰退和痴呆症发病的高质量数据。印度纵向老龄化研究统一诊断评估的第二波（LASI-DAD）旨在对印度的认知和痴呆症进行纵向评估。所有第一波参与者都被招募进行随访访谈，并从印度纵向老龄化研究中抽取了一个补充样本，该研究是一个具有全国代表性的45岁及以上印度人群体。受访者接受了一系列认知测试、老年评估和静脉采血。他们的健康和认知状况还通过与亲密家庭成员或朋友的访谈进行评估。根据临床痴呆评定量表（Clinical Dementia Rating®）进行临床共识诊断，并收集有关痴呆症风险因素的综合数据，包括神经退行性生物标志物、感觉功能和环境暴露。2022年至2024年期间，从印度22个邦和联邦属地共招募了4635名参与者，占印度人口的97.9%。应答率为84.0%，71.5%的参与者提供了静脉血样本。LASI-DAD提供了丰富的新数据，用于在印度具有全国代表性的老年人样本中纵向研究认知、痴呆症及其风险因素。纵向认知数据，连同纵向评估的生物标志物数据以及关于感觉功能和环境暴露的新数据，提供了一个独特的机会来建立风险因素与生物学定义的认知老化表型之间的关联。
