三萜类药物发现的进展。

Advances in triterpene drug discovery.

机构信息

Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, UK.

School of Chemistry, Pharmacy, and Pharmacology, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK.

出版信息

Trends Pharmacol Sci. 2024 Nov;45(11):964-968. doi: 10.1016/j.tips.2024.10.003. Epub 2024 Oct 30.

DOI:10.1016/j.tips.2024.10.003

PMID:39482199

Abstract

Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible to access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery and optimisation of a new generation of drug leads.

摘要

三萜类化合物是结构复杂的天然产物，具有有前景的治疗特性。它们对化学合成的抗性阻碍了它们在药物开发中的应用。最近的进展使得利用工程生物学方法获得和利用三萜类化合物的结构多样性成为可能，从而能够发现和优化新一代药物先导化合物。