Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street #100, Philadelphia, PA, USA.
PET Clin. 2025 Jan;20(1):25-37. doi: 10.1016/j.cpet.2024.09.010. Epub 2024 Oct 30.
Autism spectrum disorder (ASD) is a characteristically heterogeneous disorder, as multiple neurodevelopmental disorders are characterized by similar symptomology and behavior. Research has shown that individuals with ASD benefit from early intervention; neuroimaging data may reveal information that cannot be obtained from traditional behavioral analysis. This review discusses the use of structural MR imaging, functional MR imaging (fMR imaging), and PET in the detection of ASD. Larger datasets, standardized methods of collection and analysis, and more robust meta-analyses are required to implement the observed biomarkers and improve the lives of patients living with AUD.
自闭症谱系障碍（ASD）是一种具有明显异质性的疾病，因为多种神经发育障碍的特征是相似的症状和行为。研究表明，自闭症患者受益于早期干预；神经影像学数据可能揭示传统行为分析无法获得的信息。本综述讨论了结构磁共振成像、功能磁共振成像（fMRI）和正电子发射断层扫描（PET）在 ASD 检测中的应用。需要更大的数据集、标准化的采集和分析方法以及更强大的荟萃分析，以实施观察到的生物标志物，改善患有自闭症谱系障碍的患者的生活。
