Pelvic floor repair center, Dalian women and Children Medical Center (Group), Dalian, China.
Department of Orthopaedic Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Sci Rep. 2024 Nov 1;14(1):26247. doi: 10.1038/s41598-024-77471-x.
Previous studies have pointed to a potential link between Obstructive Sleep Apnea (OSA) and gastrointestinal diseases, suggesting that this relationship might be influenced by the presence of Metabolic Syndrome. However, the exact role of these factors in determining gastrointestinal diseases has not been thoroughly explored. In our study, we utilized data from the Genome-wide Association Studies (GWAS) database, focusing on OSA, metabolic syndrome characteristics such as Body Mass Index (BMI), waist circumference, triglycerides, cholesterol, hypertension, type 2 diabetes, and common gastrointestinal diseases including chronic gastritis, gastric ulcers, irritable bowel syndrome, colorectal cancer, inflammatory bowel disease, cholecystitis, nonalcoholic fatty liver, and dyspepsia. By applying Single-variable and Multi-variable Mendelian randomization methods, we aimed to assess the correlation between OSA and gastrointestinal diseases and investigate whether this correlation is influenced by metabolic syndrome. Our findings revealed a strong association between OSA and an increased risk of chronic gastritis, gastric ulcers, inflammatory bowel disease, and nonalcoholic fatty liver disease. No significant connections were found with irritable bowel syndrome, colorectal cancer, cholecystitis, or dyspepsia. Additionally, OSA was linked to metabolic syndrome traits like BMI, waist circumference, triglycerides, hypertension, and type 2 diabetes. Further analysis showed that BMI, triglycerides, and hypertension were causally related to inflammatory bowel disease; BMI, waist circumference, hypertension, and type 2 diabetes to nonalcoholic fatty liver disease; and triglycerides, hypertension, and type 2 diabetes to chronic gastritis. The multivariable analysis indicated that hypertension mediates the relationship between OSA and chronic gastritis; BMI, triglycerides, and hypertension mediate the link between OSA and inflammatory bowel disease; and waist circumference mediates the connection between OSA and nonalcoholic fatty liver disease. To wrap up, this finding helps us understand how these issues might be related and stresses the role of metabolic syndrome in preventing them, which could lessen their effect on health.
先前的研究表明阻塞性睡眠呼吸暂停（OSA）与胃肠道疾病之间可能存在关联，提示代谢综合征可能会影响这种关系。然而，这些因素在确定胃肠道疾病中的确切作用尚未得到充分探讨。在我们的研究中，我们利用了来自全基因组关联研究（GWAS）数据库的数据，重点研究了 OSA、代谢综合征特征（如体重指数（BMI）、腰围、甘油三酯、胆固醇、高血压、2 型糖尿病）以及常见的胃肠道疾病（包括慢性胃炎、胃溃疡、肠易激综合征、结直肠癌、炎症性肠病、胆囊炎、非酒精性脂肪肝和消化不良）。通过应用单变量和多变量孟德尔随机化方法，我们旨在评估 OSA 与胃肠道疾病之间的相关性，并研究这种相关性是否受代谢综合征的影响。我们的研究结果表明，OSA 与慢性胃炎、胃溃疡、炎症性肠病和非酒精性脂肪肝的患病风险增加密切相关。而与肠易激综合征、结直肠癌、胆囊炎或消化不良无显著关联。此外，OSA 与代谢综合征特征如 BMI、腰围、甘油三酯、高血压和 2 型糖尿病相关。进一步的分析表明，BMI、甘油三酯和高血压与炎症性肠病有关；BMI、腰围、高血压和 2 型糖尿病与非酒精性脂肪肝有关；甘油三酯、高血压和 2 型糖尿病与慢性胃炎有关。多变量分析表明，高血压介导了 OSA 与慢性胃炎之间的关系；BMI、甘油三酯和高血压介导了 OSA 与炎症性肠病之间的关系；而腰围则介导了 OSA 与非酒精性脂肪肝之间的关系。总的来说，这一发现有助于我们理解这些问题之间可能存在的关联，并强调了代谢综合征在预防这些问题方面的作用，这可能会减轻它们对健康的影响。
