Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Stem Cell Res Ther. 2024 Oct 31;15(1):391. doi: 10.1186/s13287-024-04010-w.
Endothelial-mesenchymal transformation (EndoMT) is the process through which endothelial cells transform into mesenchymal cells, affecting their morphology, gene expression, and function. EndoMT is a potential risk factor for cardiovascular and cerebrovascular diseases, tumor metastasis, and fibrosis. Recent research has highlighted the role of exosomes, a mode of cellular communication, in the regulation of EndoMT. Exosomes from diseased tissues and microenvironments can promote EndoMT, increase endothelial permeability, and compromise the vascular barrier. Conversely, exosomes derived from stem cells or progenitor cells can inhibit the EndoMT process and preserve endothelial function. By modifying exosome membranes or contents, we can harness the advantages of exosomes as carriers, enhancing their targeting and ability to inhibit EndoMT. This review aims to systematically summarize the regulation of EndoMT by exosomes in different disease contexts and provide effective strategies for exosome-based EndoMT intervention.
内皮-间质转化（EndoMT）是指内皮细胞向间充质细胞转化的过程，影响其形态、基因表达和功能。EndoMT 是心血管和脑血管疾病、肿瘤转移和纤维化的潜在危险因素。最近的研究强调了细胞通讯的一种模式——外泌体在调节 EndoMT 中的作用。来自病变组织和微环境的外泌体可以促进 EndoMT，增加内皮通透性，并损害血管屏障。相反，来自干细胞或祖细胞的外泌体可以抑制 EndoMT 过程并维持内皮功能。通过修饰外泌体膜或内容物，我们可以利用外泌体作为载体的优势，增强其靶向性和抑制 EndoMT 的能力。本综述旨在系统总结不同疾病背景下外泌体对 EndoMT 的调节，并为基于外泌体的 EndoMT 干预提供有效的策略。
