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胎盘缺血导致宫内生长受限的孕鼠表现出子痫前期样症状：一种新的子痫前期大鼠模型。

Intrauterine growth-restricted pregnant rats, from placental ischemic dams, display preeclamptic-like symptoms: A new rat model of preeclampsia.

机构信息

Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas, USA.

School of Social Work, Texas A & M University-Commerce, Commerce, Texas, USA.

出版信息

Physiol Rep. 2024 Nov;12(21):e70112. doi: 10.14814/phy2.70112.

DOI:10.14814/phy2.70112
PMID:39482843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11527824/
Abstract

Preeclampsia (PE) is characterized by de novo hypertension (HTN) and is often associated with intrauterine growth restriction (IUGR). Hallmarks of PE are placental ischemia, decreased nitric oxide (NO) bioavailability, oxidative stress (OS), and organ damage in the kidneys and brain. This study aims to characterize a new model of PE using pregnant IUGR rats from hypertensive placental ischemic dams. It is hypothesized that pregnant IUGR rats from hypertensive placental ischemic dams will have elevated blood pressure (BP), OS, and organ damage. In this study, pregnant rats are divided into two groups: normal pregnant (NP) and hypertensive placental ischemic dams (RUPP). Offspring from NP and RUPP dams were mated at 10 weeks of age to generate pregnant IUGR (IUGR Preg) and pregnant control (CON Preg) rats. BP and other markers of PE were evaluated during late gestation. Pregnant IUGR rats had elevated BP and systemic OS. The maternal body weight of pregnant IUGR rats and their pups' weights were decreased, while the brains were enlarged with elevated OS. In summary, pregnant IUGR rats, born from hypertensive placental ischemic dams, have HTN and increased systemic and brain OS, with larger brain sizes and smaller pups. Furthermore, this study shows that pregnant IUGR rats exhibit a preeclamptic-like phenotype, suggesting a new epigenetic model of PE.

摘要

子痫前期 (PE) 的特征是新出现的高血压 (HTN)，常伴有宫内生长受限 (IUGR)。PE 的标志是胎盘缺血、一氧化氮 (NO) 生物利用度降低、氧化应激 (OS) 和肾脏及大脑器官损伤。本研究旨在使用高血压胎盘缺血的 IUGR 大鼠来描述一种新的 PE 模型。研究假设高血压胎盘缺血的 IUGR 大鼠的血压 (BP)、OS 和器官损伤会升高。在这项研究中，将怀孕大鼠分为两组：正常怀孕 (NP) 和高血压胎盘缺血的母鼠 (RUPP)。NP 和 RUPP 母鼠的后代在 10 周龄时交配，以产生 IUGR 怀孕 (IUGR Preg) 和正常怀孕 (CON Preg) 大鼠。在妊娠晚期评估 BP 和其他 PE 标志物。IUGR 怀孕大鼠的 BP 升高和全身 OS 升高。IUGR 怀孕大鼠的母体体重和幼崽体重下降，而大脑增大，OS 升高。总之，来自高血压胎盘缺血的 IUGR 怀孕大鼠患有 HTN 以及全身性和大脑 OS 增加，大脑增大而幼崽较小。此外，本研究表明，来自高血压胎盘缺血的 IUGR 怀孕大鼠表现出类似于子痫前期的表型，提示了一种新的 PE 表观遗传模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/2633c873eefd/PHY2-12-e70112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/03fa10ba58c3/PHY2-12-e70112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/26f947d0f04c/PHY2-12-e70112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/fd028303a84c/PHY2-12-e70112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/7c2aeb892e2f/PHY2-12-e70112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/52ba166484c2/PHY2-12-e70112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/2633c873eefd/PHY2-12-e70112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/03fa10ba58c3/PHY2-12-e70112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/26f947d0f04c/PHY2-12-e70112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/fd028303a84c/PHY2-12-e70112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/7c2aeb892e2f/PHY2-12-e70112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/52ba166484c2/PHY2-12-e70112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e4e/11527824/2633c873eefd/PHY2-12-e70112-g002.jpg

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本文引用的文献

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Metabolic theory of preeclampsia: implications for maternal cardiovascular health.子痫前期的代谢理论：对母体心血管健康的影响。
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Brain Vascular Dysfunction in Mothers and Their Children Exposed to Preeclampsia.患先兆子痫的母亲及其子女的脑血管功能障碍
Hypertension. 2023 Feb;80(2):242-256. doi: 10.1161/HYPERTENSIONAHA.122.19408. Epub 2022 Aug 3.
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Animal Models of Preeclampsia: Mechanistic Insights and Promising Therapeutics.
子痫前期的动物模型：发病机制的深入了解和有前景的治疗方法。
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The etiology of preeclampsia.子痫前期的病因。
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