Buh Franklin Chu, Taiwe Germain Sotoing, Kobeissy Firas H, Wang Kevin W, Maas Andrew I R, Motah Mathieu, Meh Basil Kum, Youm Eric, Hutchinson Peter J A, Sumbele Irene Ule Ngole
Department of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon;
Panafrican Hospital Center, Douala P.O. Box 13152, Cameroon.
NeuroSci. 2023 Jul 3;4(3):164-177. doi: 10.3390/neurosci4030015. eCollection 2023 Sep.
Despite the available literature on traumatic brain injury (TBI) biomarkers elsewhere, data are limited or non-existent in sub-Saharan Africa (SSA). The aim of the study was to analyse associations in acute TBI between the admission serum biomarker concentrations and TBI severity, CT-scan findings, and outcome, as well as to explore the influence of concurrent infection. The concentrations of serum biomarkers (GFAP, NFL Tau, UCH-L1, and S100B) were measured and were detected in the samples obtained <24 h post injury. GOSE was used to evaluate the 6-month outcome. All of the biomarker levels increased with the severity of TBI, but this increase was significant only for NFL ( = 0.01). The GFAP values significantly increased ( = 0.026) in those with an unfavourable outcome. The Tau levels were higher in those who died ( = 0.017). GFAP and NFL were sensitive to CT-scan pathology ( values of 0.004 and 0.002, respectively). The S100B levels were higher ( < 0.001) in TBI patients seropositive to In conclusion, NFL was found to be sensitive to TBI severity, while NFL and GFAP were predictive of CT intracranial abnormalities. Increased levels of GFAP and Tau were associated with poorer outcomes 6 months after TBI, and the S100B levels were significantly affected by concurrent infection in TBI patients compared with the seronegative patients.
尽管在其他地方已有关于创伤性脑损伤（TBI）生物标志物的文献，但撒哈拉以南非洲（SSA）的数据有限或不存在。本研究的目的是分析急性TBI患者入院时血清生物标志物浓度与TBI严重程度、CT扫描结果及预后之间的关联，并探讨并发感染的影响。测定了血清生物标志物（GFAP、NFL Tau、UCH-L1和S100B）的浓度，并在伤后<24小时采集的样本中检测到。采用格拉斯哥预后评分扩展版（GOSE）评估6个月后的预后。所有生物标志物水平均随TBI严重程度增加而升高，但仅NFL的升高具有显著性（P = 0.01）。预后不良者的GFAP值显著升高（P = 0.026）。死亡患者的Tau水平更高（P = 0.017）。GFAP和NFL对CT扫描病理敏感（P值分别为0.004和0.002）。TBI患者中对[此处原文缺失相关感染病原体名称]血清学阳性者的S100B水平更高（P < 0.001）。总之，发现NFL对TBI严重程度敏感，而NFL和GFAP可预测CT颅内异常。TBI后6个月，GFAP和Tau水平升高与较差的预后相关，与血清学阴性患者相比，TBI患者并发感染对S100B水平有显著影响。
