Department of Neurology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands.
Faculty of Science, Department of Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, the Netherlands.
Neurosci Biobehav Rev. 2022 Jan;132:154-168. doi: 10.1016/j.neubiorev.2021.11.036. Epub 2021 Nov 23.
VISSER, K., M. Koggel, J. Blaauw, H.J.v.d. Horn, B. Jacobs, and J.v.d. Naalt. Blood based biomarkers of inflammation in mild traumatic brain injury: A systematic review. NEUROSCI BIOBEHAV REV XX(X) XXX-XXX, 2021. - Inflammation is an important secondary physiological response to traumatic brain injury (TBI). Most of the current knowledge on this response is derived from research in moderate and severe TBI. In this systematic review we summarize the literature on clinical studies measuring blood based inflammatory markers following mild traumatic brain injury (mTBI) and identify the value of inflammatory markers as biomarkers. Twenty-three studies were included. This review suggests a distinct systemic inflammatory response following mTBI, quantifiable within 6 h up to 12 months post-injury. Interleukin-6 is the most promising biomarker for the clinical diagnosis of brain injury while interleukin-10 is a potential candidate for triaging CT scans. The diagnostic and prognostic utility of inflammatory markers may be more fully appreciated as a component of a panel of biomarkers. However, discrepancies in study design, analysis and reporting make it difficult to draw any definite conclusions. For the same reasons, a meta-analysis was not possible. We provide recommendations to follow standardized methodologies to allow for reproducibility of results in future studies.
维斯瑟，K.，M. 科格尔，J. 布劳，H.J.范德霍恩，B. 雅各布斯，和 J.范德纳尔特。轻度创伤性脑损伤中的炎症血液生物标志物：系统评价。神经科学与生物行为评论 XX（X）XXX-XXX，2021. - 炎症是创伤性脑损伤（TBI）的重要继发性生理反应。目前关于这种反应的大部分知识来自中度和重度 TBI 的研究。在这个系统评价中，我们总结了关于测量轻度创伤性脑损伤（mTBI）后血液炎症标志物的临床研究文献，并确定了炎症标志物作为生物标志物的价值。共纳入 23 项研究。本综述表明，mTBI 后存在明显的全身炎症反应，可在损伤后 6 小时至 12 个月内定量。白细胞介素-6 是最有前途的脑损伤临床诊断生物标志物，而白细胞介素-10 是 CT 扫描分诊的潜在候选者。炎症标志物的诊断和预后效用可能作为生物标志物组合的一部分得到更充分的认识。然而，研究设计、分析和报告的差异使得很难得出任何明确的结论。出于同样的原因，无法进行荟萃分析。我们提供了遵循标准化方法的建议，以允许在未来的研究中重现结果。
