肌痛性脑脊髓炎/慢性疲劳综合征自然杀伤细胞细胞毒性的荟萃分析。

Meta-analysis of natural killer cell cytotoxicity in myalgic encephalomyelitis/chronic fatigue syndrome.

机构信息

Department of Medicine, Georgetown University, Washington, DC, United States.

National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, QLD, Australia.

出版信息

Front Immunol. 2024 Oct 17;15:1440643. doi: 10.3389/fimmu.2024.1440643. eCollection 2024.

DOI:10.3389/fimmu.2024.1440643

PMID:39483457

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11524851/

Abstract

UNLABELLED

Reduced natural killer (NK) cell cytotoxicity is the most consistent immune finding in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Meta-analysis of the published literature determined the effect size of the decrement in ME/CFS. Databases were screened for papers comparing NK cell cytotoxicity in ME/CFS and healthy controls. A total of 28 papers and 55 effector:target cell ratio (E:T) data points were collected. Cytotoxicity in ME/CFS was significantly reduced to about half of healthy control levels, with an overall Hedges' g of 0.96 (0.75-1.18). Heterogeneity was high but was explained by the range of E:T ratios, different methods, and potential outliers. The outcomes confirm reproducible NK cell dysfunction in ME/CFS and will guide studies using the NK cell model system for pathomechanistic investigations.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero/, identifier CRD42024542140.

摘要

未标记

自然杀伤 (NK) 细胞细胞毒性降低是肌痛性脑脊髓炎/慢性疲劳综合征 (ME/CFS) 中最一致的免疫发现。对已发表文献的荟萃分析确定了 ME/CFS 中 NK 细胞毒性降低的效应大小。筛选数据库以查找比较 ME/CFS 和健康对照组 NK 细胞细胞毒性的论文。共收集了 28 篇论文和 55 个效应器：靶细胞比 (E:T) 数据点。ME/CFS 中的细胞毒性明显降低到健康对照组水平的一半左右，总体 Hedges'g 为 0.96（0.75-1.18）。异质性很高，但可以通过 E:T 比值、不同方法和潜在异常值来解释。这些结果证实了 ME/CFS 中 NK 细胞功能障碍的可重复性，将指导使用 NK 细胞模型系统进行发病机制研究。