Ji Lichen, Huang Jiaqing, Yu Liting, Jin Huihui, Hu Xuanhan, Sun Yuan, Yin Feng, Cai Yu
Zhejiang Chinese Medical University, Hangzhou 310053, China; Center for Rehabilitation Medicine Rehabilitation & Sports Medicine Research Institute of Zhejiang Province Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China; Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China.
Zhejiang Chinese Medical University, Hangzhou 310053, China; Center for Rehabilitation Medicine Rehabilitation & Sports Medicine Research Institute of Zhejiang Province Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou 310014, China; Department of Hematology, Hangzhou First People's Hospital, Hangzhou 310003, China.
Int J Pharm. 2024 Nov 15;665:124633. doi: 10.1016/j.ijpharm.2024.124633. Epub 2024 Aug 24.
Osteosarcoma (OS) is a prevalent and highly malignant bone tumor, characterized by its aggressive nature, invasiveness, and rapid progression, contributing to a high mortality rate, particularly among adolescents. Traditional treatment modalities, including surgical resection, radiotherapy, and chemotherapy, face significant challenges, especially in addressing chemotherapy resistance and managing postoperative recurrence and metastasis. Phototherapy (PT), encompassing photodynamic therapy (PDT) and photothermal therapy (PTT), offers unique advantages such as low toxicity, minimal drug resistance, selective destruction, and temporal control, making it a promising approach for the clinical treatment of various malignant tumors. Constructing multifunctional delivery systems presents an opportunity to effectively combine tumor PDT, PTT, and chemotherapy, creating a synergistic anti-tumor effect. This review aims to consolidate the progress in the application of novel delivery system-mediated phototherapy in osteosarcoma. By summarizing advancements in this field, the objective is to propose a rational combination therapy involving targeted delivery systems and phototherapy for tumors, thereby expanding treatment options and enhancing the prognosis for osteosarcoma patients. In conclusion, the integration of innovative delivery systems with phototherapy represents a promising avenue in osteosarcoma treatment, offering a comprehensive approach to overcome challenges associated with conventional treatments and improve patient outcomes.
骨肉瘤（OS）是一种常见且高度恶性的骨肿瘤，其特点是具有侵袭性、浸润性和快速进展性，导致死亡率很高，尤其是在青少年中。传统的治疗方式，包括手术切除、放疗和化疗，面临着重大挑战，特别是在解决化疗耐药性以及处理术后复发和转移方面。光疗（PT），包括光动力疗法（PDT）和光热疗法（PTT），具有独特的优势，如低毒性、最小耐药性、选择性破坏和时间可控性，使其成为各种恶性肿瘤临床治疗的一种有前景的方法。构建多功能递送系统为有效结合肿瘤光动力疗法、光热疗法和化疗提供了机会，从而产生协同抗肿瘤效应。本综述旨在巩固新型递送系统介导的光疗在骨肉瘤应用中的进展。通过总结该领域的进展，目的是提出一种涉及肿瘤靶向递送系统和光疗的合理联合治疗方法，从而扩大治疗选择并改善骨肉瘤患者的预后。总之，创新递送系统与光疗的整合在骨肉瘤治疗中是一条有前景的途径，提供了一种全面的方法来克服与传统治疗相关的挑战并改善患者预后。
