Chandler W L, Schmer G
Clin Chem. 1986 Mar;32(3):505-7.
We evaluated a new type of dynamic viscometer, the Sonoclot Coagulation Analyzer, for use in measuring the viscosity of whole-blood and plasma. Such information can be useful in monitoring patients with hyperviscosity syndromes, e.g., from multiple myeloma. A vibrating Teflon or plastic probe continuously measures dynamic viscosity. The instrument can be calibrated to measure a range of viscosities from 0.69 to 23 cP (mN X s X m-2) or more. The coefficient of variation at 0.69 cP was 3-4% for measurements with the Teflon probe, 7-9% with the plastic probe. Viscosity measured at 37 degrees C for plasma and whole-blood samples from 20 normal patients was 1.22 (SD 0.05) cP and 3.63 (SD 0.52) cP, respectively. Dynamic viscosity measured in blood samples from a single source, with contrived hematocrits ranging from 0 to 89%, increased exponentially as a function of hematocrit, confirming previous studies. Overall, we found this instrument simple and quick to operate, producing accurate, precise viscosity measurements over at least a 40-fold range of viscosity.
我们评估了一种新型动态粘度计——声凝块凝血分析仪，用于测量全血和血浆的粘度。此类信息对于监测高粘滞综合征患者（例如来自多发性骨髓瘤患者）可能有用。一个振动的聚四氟乙烯或塑料探头持续测量动态粘度。该仪器可校准以测量范围从0.69至23厘泊（mN×s×m-2）或更高的一系列粘度。使用聚四氟乙烯探头测量时，在0.69厘泊下的变异系数为3 - 4%，使用塑料探头时为7 - 9%。对20名正常患者的血浆和全血样本在37摄氏度下测量的粘度分别为1.22（标准差0.05）厘泊和3.63（标准差0.52）厘泊。在来自单一来源、人为设定血细胞比容范围从0至89%的血液样本中测量的动态粘度，作为血细胞比容的函数呈指数增加，这证实了先前的研究。总体而言，我们发现该仪器操作简单快捷，在至少40倍的粘度范围内能产生准确、精确的粘度测量结果。
