FAAH基因rs324420多态性中的遗传变异及其与CRHR1基因rs110402和CNR1基因rs2180619的相互作用在军事部署后焦虑及创伤相关症状中的作用
The Role of Genetic Variations in the FAAH rs324420 Polymorphism and its Interaction with CRHR1 rs110402 and CNR1 rs2180619 in Anxiety and- Trauma Related Symptoms After Military Deployment.
作者信息
Leen Nadia, de Weijer Antoin, Boks Marco, Baas Johanna, Vermetten Eric, Geuze Elbert
机构信息
Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands.
Brain Research and Innovation Centre, Ministry of Defence, Utrecht, The Netherlands.
出版信息
Chronic Stress (Thousand Oaks). 2024 Oct 7;8:24705470241285828. doi: 10.1177/24705470241285828. eCollection 2024 Jan-Dec.
BACKGROUND
During military deployment, stress regulation is vital to protect against the development of anxiety and trauma-related symptoms. Brain endocannabinoids play an important role in stress regulation and previous research has shown that genetic variations in the FAAH rs324420 polymorphism demonstrate protective effects during stress. In addition, this polymorphism shows interactions with the CRHR1 and CNR1 polymorphisms on anxiety. The present study examines whether genetic variations of the FAAH, CRHR1 and CNR1 polymorphisms interact with the development of anxiety and trauma related symptoms in military veterans.
METHODS
Veterans (N = 949) who went on military deployment and experienced a stressful event were genotyped for FAAH rs324420, CRHR1 rs110402 and CNR1 rs2180619. Anxiety and trauma symptoms were measured pre-deployment and 6 months after deployment. Anxiety was measured with the anxiety subscale of the Symptom Checklist-90 (SCL-90) and trauma with the Self-Rating Inventory for PTSD (SRIP).
RESULTS
Covariance Pattern Models demonstrated no significant relation of genetic variations in FAAH rs324420 on anxiety and PTSD symptoms from pre-deployment to 6 months after military deployment. Additionally, we investigated interactions between the FAAH s324420, CRHR1 rs110402 and CNR1 rs2180619 polymorphisms. This also demonstrated no significant effects on anxiety and PTSD symptoms pre- to post deployment. However, the covariate of childhood trauma that was included in the models was significant in all these models.
CONCLUSION
Genetic variations in FAAH rs324420 and its interactions with CRHR1 rs110402 and CNR1 rs2180619 are not related to the development of anxiety and trauma-related symptoms. The study however, indicates the importance of considering childhood trauma in the investigation of the effects of polymorphisms that are related to the endocannabinoid system on the development of anxiety and PTSD symptoms.
背景
在军事部署期间，压力调节对于预防焦虑和创伤相关症状的出现至关重要。脑内源性大麻素在压力调节中起重要作用，先前的研究表明，脂肪酸酰胺水解酶（FAAH）rs324420多态性的基因变异在压力期间具有保护作用。此外，这种多态性显示出与促肾上腺皮质激素释放激素受体1（CRHR1）和大麻素受体1（CNR1）多态性在焦虑方面存在相互作用。本研究旨在探讨FAAH、CRHR1和CNR1多态性的基因变异是否与退伍军人焦虑和创伤相关症状的发生相互作用。
方法
对949名参加过军事部署并经历过应激事件的退伍军人进行FAAH rs324420、CRHR1 rs110402和CNR1 rs2180619基因分型。在部署前和部署后6个月测量焦虑和创伤症状。焦虑用症状自评量表90（SCL - 90）的焦虑分量表测量，创伤用创伤后应激障碍自评量表（SRIP）测量。
结果
协方差模式模型显示，从部署前到军事部署后6个月，FAAH rs324420的基因变异与焦虑和创伤后应激障碍症状之间无显著关系。此外，我们研究了FAAH s324420、CRHR1 rs110402和CNR1 rs2180619多态性之间的相互作用。这也表明在部署前后对焦虑和创伤后应激障碍症状无显著影响。然而，模型中纳入的童年创伤协变量在所有这些模型中均具有显著性。
结论
FAAH rs324420的基因变异及其与CRHR1 rs110402和CNR1 rs2180619的相互作用与焦虑和创伤相关症状的发生无关。然而，该研究表明，在调查与内源性大麻素系统相关的多态性对焦虑和创伤后应激障碍症状发生的影响时，考虑童年创伤具有重要意义。
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