Baba T, Ochiya T, Yamaguchi K, Baba A, Takase T, Uyeno K
Clin Immunol Immunopathol. 1986 Apr;39(1):24-36. doi: 10.1016/0090-1229(86)90202-3.
Sarcoidosis sera were found to have the ability to induce normal human monocytes to spread. Gel filtration of sarcoidosis sera on Sephadex G-200 showed that the factor mainly responsible for this activity had a molecular weight of about 70,000. The spreading factor also possessed the ability to increase all cell size of normal human monocytes as well as to increase their phagocytosis and glucose consumption. Accordingly, the spreading factor seems to be considered as a monocyte activating factor. Sarcoidosis sera showed a macrophage migration inhibitory activity, as well. On Sephadex G-200 column chromatography of the sera, the most obvious inhibitory activity was eluted in the fraction with a molecular weight of about 45,000. The macrophage migration inhibitory factor had the ability neither to increase cell size of normal human monocytes nor to increase their phagocytosis and glucose consumption.
结节病血清被发现有诱导正常人单核细胞铺展的能力。在葡聚糖凝胶G - 200上对结节病血清进行凝胶过滤显示，主要负责这种活性的因子分子量约为70,000。这种铺展因子还具有增加正常人单核细胞的所有细胞大小以及增加其吞噬作用和葡萄糖消耗的能力。因此，这种铺展因子似乎可被视为单核细胞激活因子。结节病血清也表现出巨噬细胞迁移抑制活性。在血清的葡聚糖凝胶G - 200柱色谱分析中，最明显的抑制活性在分子量约为45,000的级分中被洗脱出来。巨噬细胞迁移抑制因子既没有增加正常人单核细胞大小的能力，也没有增加其吞噬作用和葡萄糖消耗的能力。
