Baba T, Yamaguchi K, Ochiya T, Baba A, Takase T, Suko M, Uyeno K
Clin Immunol Immunopathol. 1986 Apr;39(1):37-48. doi: 10.1016/0090-1229(86)90203-5.
The normal human monocytes pretreated with the monocyte activating factor found in sarcoidosis sera were shown to secrete a factor which induced normal human monocytes to spread as well as to increase their cell size. Phagocytosis and glucose consumption of normal human monocytes were also increased by this secondarily obtained factor. Its molecular weight was about 70,000. These results indicate that this secondary factor may be the same substance as the monocyte activating factor found in sarcoidosis sera. The normal human monocytes pretreated with the monocyte activating factor were also shown to liberate a factor which generated macrophage migration inhibitory factor in cooperation with normal human sera.
用结节病血清中发现的单核细胞激活因子预处理的正常人单核细胞，被证明能分泌一种因子，该因子可诱导正常人单核细胞铺展并增大细胞大小。这种继发获得的因子还能增加正常人单核细胞的吞噬作用和葡萄糖消耗。其分子量约为70,000。这些结果表明，这种继发因子可能与结节病血清中发现的单核细胞激活因子是同一物质。用单核细胞激活因子预处理的正常人单核细胞还被证明能释放一种因子，该因子与正常人血清协同作用可产生巨噬细胞移动抑制因子。
