Paulson Abigail L, Zhang Lu, Prichard Ashley M, Singer Annabelle C
Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, 30332, USA.
National Institute of Mental Health, NIH, Bethesda, 20892, MD.
bioRxiv. 2024 Oct 23:2024.10.23.619408. doi: 10.1101/2024.10.23.619408.
40 Hz sensory stimulation ("flicker") has emerged as a new technique to potentially mitigate pathology and improve cognition in mouse models of Alzheimer's disease (AD) pathology. However, it remains unknown how 40 Hz flicker affects neural codes essential for memory. Accordingly, we investigate the effects of 40 Hz flicker on neural representations of experience in the hippocampus of the 5XFAD mouse model of AD by recording 1000s of neurons during a goal-directed spatial navigation task. We find that an hour of daily exposure to 40 Hz audio-visual stimulation over 8 days leads to higher coordination between hippocampal subregions CA3 and CA1 during navigation. Consistent with CA3's role in generating sequential activity that represents future positions, 40 Hz flicker exposure increased prospective coding of future positions. In turn, prospective coding was more prominent during efficient navigation behavior. Our findings show how 40 Hz flicker enhances key hippocampal activity during behavior that is important for memory.
40赫兹感觉刺激（“闪烁”）已成为一种新技术，有望减轻阿尔茨海默病（AD）病理小鼠模型中的病理状况并改善认知。然而，40赫兹闪烁如何影响记忆所必需的神经编码仍不清楚。因此，我们通过在目标导向的空间导航任务中记录数千个神经元，研究40赫兹闪烁对5XFAD AD小鼠模型海马体中经验的神经表征的影响。我们发现，在8天内每天一小时暴露于40赫兹视听刺激下，会导致导航过程中海马体CA3和CA1子区域之间更高的协调性。与CA3在生成代表未来位置的序列活动中的作用一致，40赫兹闪烁暴露增加了对未来位置的前瞻性编码。反过来，在高效导航行为期间，前瞻性编码更为突出。我们的研究结果表明了40赫兹闪烁如何在对记忆很重要的行为过程中增强关键的海马体活动。
