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通过人类胰腺癌单细胞RNA测序揭示的成纤维细胞动态演变

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.

作者信息

Dimitrieva Slavica, Harrison Jon M, Chang Jonathan, Piquet Michelle, Mino-Kenudson Mari, Gabriel Millicent, Sagar Vivek, Horn Heiko, Lage Kasper, Kim Julie, Li Gang, Weng Shaobu, Harris Cynthia, Kulkarni Anupriya S, Ting David T, Qadan Motaz, Fagenholz Peter J, Ferrone Cristina R, Grauel Angelo L, Laszewski Tyler, Raza Alina, Riester Markus, Somerville Tim, Wagner Joel P, Dranoff Glenn, Engelman Jeffrey A, Kauffmann Audrey, Leary Rebecca, Warshaw Andrew L, Lillemoe Keith D, Fernández-Del Castillo Carlos, Ruddy David A, Liss Andrew S, Cremasco Viviana

机构信息

Oncology Data Science, Novartis Biomedical Research, Basel, Switzerland.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

Cancer Res Commun. 2024 Dec 1;4(12):3049-3066. doi: 10.1158/2767-9764.CRC-23-0489.

DOI:10.1158/2767-9764.CRC-23-0489
PMID:39485038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11609929/
Abstract

Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.

摘要

胰腺癌仍然是一个尚未得到充分满足的重大医疗需求。了解这种疾病中基质与癌细胞之间的相互作用可能会揭示治疗干预的新机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/644adbdc58a3/crc-23-0489_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/110e9e7edf3e/crc-23-0489_f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/58db2e594585/crc-23-0489_f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/1244a0a84216/crc-23-0489_f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/fad2180c174a/crc-23-0489_f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/644adbdc58a3/crc-23-0489_f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/110e9e7edf3e/crc-23-0489_f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/30248b99feda/crc-23-0489_f2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa22/11609929/644adbdc58a3/crc-23-0489_f7.jpg

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本文引用的文献

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Elife. 2023 Jun 23;12:e86125. doi: 10.7554/eLife.86125.
2
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.不断演变的肿瘤微环境：从癌症起始到转移灶生长
Cancer Cell. 2023 Mar 13;41(3):374-403. doi: 10.1016/j.ccell.2023.02.016.
3
From gatekeepers to providers: regulation of immune functions by cancer-associated fibroblasts.从守门人到提供者：癌症相关成纤维细胞对免疫功能的调节
Trends Cancer. 2023 May;9(5):421-443. doi: 10.1016/j.trecan.2023.01.007. Epub 2023 Mar 2.
4
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin.多组学分析揭示了癌症相关成纤维细胞表型在物种和组织起源上的保守性。
Cancer Cell. 2022 Nov 14;40(11):1392-1406.e7. doi: 10.1016/j.ccell.2022.09.015. Epub 2022 Oct 20.
5
LRRC15 myofibroblasts dictate the stromal setpoint to suppress tumour immunity.LRRC15 肌成纤维细胞决定了基质设定点以抑制肿瘤免疫。
Nature. 2022 Nov;611(7934):148-154. doi: 10.1038/s41586-022-05272-1. Epub 2022 Sep 28.
6
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.单细胞和空间转录组分析鉴定与新辅助治疗相关的胰腺癌多细胞动力学特征。
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