通过人类胰腺癌单细胞RNA测序揭示的成纤维细胞动态演变

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.

作者信息

Dimitrieva Slavica, Harrison Jon M, Chang Jonathan, Piquet Michelle, Mino-Kenudson Mari, Gabriel Millicent, Sagar Vivek, Horn Heiko, Lage Kasper, Kim Julie, Li Gang, Weng Shaobu, Harris Cynthia, Kulkarni Anupriya S, Ting David T, Qadan Motaz, Fagenholz Peter J, Ferrone Cristina R, Grauel Angelo L, Laszewski Tyler, Raza Alina, Riester Markus, Somerville Tim, Wagner Joel P, Dranoff Glenn, Engelman Jeffrey A, Kauffmann Audrey, Leary Rebecca, Warshaw Andrew L, Lillemoe Keith D, Fernández-Del Castillo Carlos, Ruddy David A, Liss Andrew S, Cremasco Viviana

机构信息

Oncology Data Science, Novartis Biomedical Research, Basel, Switzerland.

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

Cancer Res Commun. 2024 Dec 1;4(12):3049-3066. doi: 10.1158/2767-9764.CRC-23-0489.

Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.