细胞系中同源重组缺陷的泛癌分析
Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines.
作者信息
Dodson Anne E, Shenker Sol, Sullivan Pamela, Nayak Sumeet U, Middleton Chris, McGuire Michael, Chipumuro Edmond, Mishina Yuji, Tobin Erica R, Cadzow Louise, Wylie Andrew A, Sangurdekar Dipen
机构信息
KSQ Therapeutics, Lexington, Massachusetts.
出版信息
Cancer Res Commun. 2024 Dec 1;4(12):3084-3098. doi: 10.1158/2767-9764.CRC-24-0316.
Abstract
HRD is common in cancer and can be exploited therapeutically, as it sensitizes cells to DNA-damaging agents. Here, we scored more than 1,300 cancer cell lines for HRD using two different bioinformatic approaches, thereby enabling large-scale analyses that provide insights into the etiology and features of HRD.
摘要
同源重组缺陷（HRD）在癌症中很常见，并且可用于治疗，因为它使细胞对DNA损伤剂敏感。在这里，我们使用两种不同的生物信息学方法对1300多个癌细胞系进行了HRD评分，从而能够进行大规模分析，深入了解HRD的病因和特征。
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