Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA.
J Gen Physiol. 2024 Dec 2;156(12). doi: 10.1085/jgp.202413622. Epub 2024 Nov 1.
Decades of research into striated muscle have provided a robust understanding of the structure and function of the sarcomere and its protein constituents. However, a handful of sarcomere proteins remain that have had little to no functional characterization. These are typically proteins that are highly muscle-type specific or are products of alternative start sites or alternative splicing.
几十年来对横纹肌的研究为肌节及其蛋白成分的结构和功能提供了坚实的理解。然而,仍有少数肌节蛋白几乎没有或没有功能特征。这些通常是高度肌肉特异性的蛋白,或者是替代起始位点或选择性剪接的产物。