Liu Suling, Wang Yuan, Feng Jiawen, Liu Zhihua, Zhou Shengtao
State Key Laboratory of Genetic Engineering, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Cancer Institutes, Shanghai, China.
Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Cancer Discov. 2024 Nov 1;14(11):2041-2046. doi: 10.1158/2159-8290.CD-24-0833.
Despite an increasingly detailed understanding of cancer hallmarks at molecular or atomic resolution, most studies, however, fall short of investigating the systemic interactions of cancer with the human body. We propose to investigate the hallmarks of cancer from an organ-wide macroscopic view, discuss the challenges in preclinical and clinical research to study the cross-organ regulation of cancer together with potential directions to overcome these challenges, and foresee how this holistic view may be translated into more effective therapies.
尽管人们对癌症特征的理解在分子或原子水平上越来越详细，但大多数研究仍未能研究癌症与人体的系统性相互作用。我们建议从器官整体宏观角度研究癌症的特征，讨论临床前和临床研究中共同研究癌症跨器官调节的挑战以及克服这些挑战的潜在方向，并预见这种整体观点如何转化为更有效的治疗方法。
