Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Coenzyme R Research Institute, Tehran, Iran.
Mol Biol Rep. 2024 Nov 1;51(1):1113. doi: 10.1007/s11033-024-10057-y.
Spinal cord injury (SCI) is damage to the spinal cord that permanently or temporarily disrupts its function, causing considerable autonomic, sensory, and motor disorders, and involves between 10 and 83 cases per million yearly. Traumatic SCI happens following primary acute mechanical damage, leading to injury to the spinal cord tissue and worsening clinical outcomes. The present therapeutic strategies for this complex disease fundamentally rely on surgical approaches and conservative remedies. However, these modalities are not effective enough for neurological recovery. Therefore, it is necessary to discover more efficient methods to treat patients with SCI. Today, considerable attention has been drawn to bioactive compounds-based remedies and stem cell therapy for curing various ailments and disorders, such as neurological diseases. Some researchers have recommended that harnessing curcumin, a polyphenol obtained from turmeric, in combination with stem cells, like mesenchymal stem cells, neural stem cells, and ependymal stem cells, can remarkably improve neurological recovery-related parameters more effective than the treatment with these two methods separately in experimental models. Hereby, this literature review delves into the functionality of curcumin combined with stem cells in treating SCI with a focus on cellular and molecular mechanisms.
脊髓损伤（SCI）是指脊髓受到损伤，导致其功能永久性或暂时受损，引起严重的自主神经、感觉和运动障碍，每年每百万人中有 10 到 83 例。外伤性 SCI 是在原发性急性机械损伤后发生的，导致脊髓组织损伤，并使临床预后恶化。目前，针对这种复杂疾病的治疗策略主要依赖于手术方法和保守治疗。然而，这些方法对于神经功能恢复的效果并不理想。因此，有必要探索更有效的方法来治疗 SCI 患者。如今，基于生物活性化合物的治疗方法和干细胞疗法已引起人们的广泛关注，用于治疗各种疾病和障碍，如神经疾病。一些研究人员建议，利用姜黄素（一种从姜黄中提取的多酚）与间充质干细胞、神经干细胞和室管膜干细胞等干细胞联合使用，可以显著改善实验模型中神经功能恢复相关参数，其效果优于这两种方法单独使用。因此，本文综述了姜黄素联合干细胞在治疗 SCI 中的作用，重点探讨了其细胞和分子机制。
