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固着液滴悬浮液中的前沿追踪与凝胶化：它们能告诉我们关于人类血液的什么信息？

Front-Tracking and Gelation in Sessile Droplet Suspensions: What Can They Tell Us about Human Blood?

作者信息

Bhatt Sheila, Smethurst Peter A, Garnier Gil, Routh Alexander F

机构信息

Institute for Energy and Environmental Flows, University of Cambridge, Bullard Laboratories, Madingley Road, Cambridge, CB3 0EZ, United Kingdom.

Component Development Laboratory, NHS Blood and Transplant, Cambridge Donor Centre, Cambridge, CB2 0PT, United Kingdom.

出版信息

Biomacromolecules. 2024 Dec 9;25(12):7594-7607. doi: 10.1021/acs.biomac.4c00753. Epub 2024 Nov 1.

DOI:10.1021/acs.biomac.4c00753
PMID:39486045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11632657/
Abstract

Recently developed imaging techniques have been used to examine the redistribution of human red blood cells and comparator particles dispersed in carrier fluids within evaporating droplets. We demonstrate that progressive gelation initiates along an annular front, isolating a central pool that briefly remains open to particulate advection before gelation completes across the droplet center. Transition to an elastic solid is evidenced by cracking initiating proximal to front locations. The arrested flow of cellular components, termed a "halted front", has been investigated using a time-lapse analysis "signature". The presence of a deformable biocellular component is seen to be essential for front-halting. We show a dependence of front-halt radius on cell volume-fraction, potentially offering a low-cost means of measuring hematocrit. A simple model yields an estimate of the gel zero-shear yield-stress. This approach to understanding the drying dynamics of blood droplets may lead to a new generation of point-of-care diagnostics.

摘要

最近开发的成像技术已被用于研究分散在蒸发液滴内载体流体中的人类红细胞和对照颗粒的重新分布。我们证明，渐进凝胶化沿着环形前沿开始，隔离出一个中央池，在凝胶化穿过液滴中心完成之前，该中央池短暂地保持对颗粒平流开放。在前沿位置附近开始出现裂纹，这证明了向弹性固体的转变。使用延时分析“特征”研究了细胞成分的停滞流动，即“停滞前沿”。可变形生物细胞成分的存在被认为是前沿停滞的关键。我们表明前沿停滞半径与细胞体积分数有关，这可能提供一种低成本的测量血细胞比容的方法。一个简单的模型得出了凝胶零剪切屈服应力的估计值。这种理解血滴干燥动力学的方法可能会带来新一代的即时诊断技术。

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本文引用的文献

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Optical absorbance profilometry for tracking time-resolved particle redistribution in high volume fraction colloidal droplets.用于跟踪高体积分数胶体液滴中时间分辨颗粒再分布的光吸收轮廓测量法。
Sci Rep. 2024 Jan 5;14(1):637. doi: 10.1038/s41598-024-51250-0.
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Dried blood drops on vertical surfaces.垂直表面上的干血滴。
Colloids Surf B Biointerfaces. 2024 Feb;234:113716. doi: 10.1016/j.colsurfb.2023.113716. Epub 2023 Dec 19.
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Optical profilometry for forensic bloodstain imaging.光学轮廓术在法医血斑成像中的应用。
Microsc Res Tech. 2023 Oct;86(10):1401-1408. doi: 10.1002/jemt.24338. Epub 2023 May 3.
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Drying of bio-colloidal sessile droplets: Advances, applications, and perspectives.生物胶体固着液滴的干燥：进展、应用与展望
Adv Colloid Interface Sci. 2023 Apr;314:102870. doi: 10.1016/j.cis.2023.102870. Epub 2023 Mar 9.
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Patterns in Dried Droplets to Detect Unfolded BSA.检测未折叠 BSA 的干燥液滴中的模式。
Sensors (Basel). 2022 Feb 3;22(3):1156. doi: 10.3390/s22031156.
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The internal flow in an evaporating human blood plasma drop.蒸发的人血浆滴内的流动。
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Controlling Droplet Marangoni Flows to Improve Microscopy-Based TB Diagnosis.控制液滴马兰戈尼流以改善基于显微镜的结核病诊断
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Patterns from dried drops as a characterisation and healthcare diagnosis technique, potential and challenges: A review.干燥液滴图案作为一种特征描述和医疗保健诊断技术：潜力与挑战综述。
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