Nguyen Thi Hanh, Wang San-Lang, Nguyen Van Bon
Doctoral Program in Applied Sciences, Tamkang University, New Taipei City 25137, Taiwan; Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan.
Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan.
Int J Biol Macromol. 2024 Dec;282(Pt 3):137051. doi: 10.1016/j.ijbiomac.2024.137051. Epub 2024 Oct 30.
Polydeoxyribonucleotide (PDRN) is a registered DNA-derived proprietary drug containing a mixture of DNA fragments of molecular weights of 50 and 1500 kDa extracted mainly from salmon with a highly pure active substance (>95 %). It has many valuable medicinal effects and multi-functions related to cosmeceuticals. In-vivo tests and even clinical trials have confirmed this substance as non-toxic. Its promising bioactivities and safety profile have prompted increasing research and discovery of this active ingredient. However, most previous review papers have only focused on the bioactivities of PDRN in medicine and mainly evaluated the efficiency of salmon-derived sources. Only one review has elucidated the capacity of PDRN as promising anti-aging without mentioning other effects in cosmeceuticals. Thus, an overview of novel sources for the extraction of PDRN and their functions in the cosmeceuticals field is lacking, and is the main topic of discussion in this review. Besides general information about PDRN, this review evaluated the advantages and disadvantages of different novel sources and procedures for PDRN extraction. The bioactivities of PDRN regarding cosmeceuticals are also elucidated comprehensively. This review aims to supply worthy scientific information for further studies on PDRN extraction and its bioactivity in cosmeceuticals.
聚脱氧核糖核苷酸（PDRN）是一种注册的源自DNA的专利药物，含有主要从鲑鱼中提取的分子量为50和1500 kDa的DNA片段混合物，其活性物质纯度很高（>95%）。它具有许多有价值的药用功效以及与药妆品相关的多功能性。体内试验甚至临床试验均已证实该物质无毒。其有前景的生物活性和安全性促使人们对这种活性成分展开越来越多的研究与发现。然而，此前大多数综述文章仅关注PDRN在医学方面的生物活性，且主要评估源自鲑鱼的原料的功效。仅有一篇综述阐述了PDRN有作为抗老化剂的潜力，但未提及在药妆品中的其他作用。因此，缺乏对PDRN提取新来源及其在药妆品领域功能的概述，而这正是本综述讨论的主要话题。除了关于PDRN的一般信息外，本综述评估了不同PDRN提取新来源和提取方法的优缺点。还全面阐述了PDRN在药妆品方面的生物活性。本综述旨在为进一步研究PDRN提取及其在药妆品中的生物活性提供有价值的科学信息。
