Department of Pediatrics, Weill Cornell Medicine, 413 East 69th Street, BB-869E, New York City, NY 10021, USA.
Department of Pediatrics, Weill Cornell Medicine, Drukier Institute for Children's Health, 413 East 69th Street, New York City, NY 10021, USA.
Clin Perinatol. 2024 Dec;51(4):769-782. doi: 10.1016/j.clp.2024.08.007. Epub 2024 Sep 11.
Despite increased uptake of antiretroviral therapy (ART) among pregnant people living with human immunodeficiency virus (HIV), vertical transmission remains the most important route of pediatric HIV acquisition. The numbers of HIV acquisitions in infancy have remained alarmingly stagnant in recent years. It is evident that additional strategies that can synergize with ART will be required to end the pediatric HIV epidemic. In this review, we discuss the potential for immune-based interventions that can be administered in conjunction with current ART-based strategies to the birthing parent for prevention of vertical transmission of HIV-1, and the potential challenges associated with each approach.
尽管感染人类免疫缺陷病毒（HIV）的孕妇越来越多地接受抗逆转录病毒治疗（ART），但垂直传播仍然是儿童 HIV 感染的最重要途径。近年来，婴儿 HIV 感染的数量仍然惊人地停滞不前。显然，需要与 ART 协同作用的额外策略，才能终结儿童 HIV 流行。在这篇综述中，我们讨论了联合当前基于 ART 的策略，向分娩母亲提供免疫干预以预防 HIV-1 垂直传播的可能性，以及每种方法所涉及的潜在挑战。
