人类免疫缺陷病毒与母乳喂养：在联合抗逆转录病毒疗法的现代时代，临床注意事项和传播机制。
Human Immunodeficiency Virus and Breastfeeding: Clinical Considerations and Mechanisms of Transmission in the Modern Era of Combined Antiretroviral Therapy.
机构信息
Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Earlham College, Richmond, IN 47374, USA.
出版信息
Clin Perinatol. 2024 Dec;51(4):783-799. doi: 10.1016/j.clp.2024.08.001. Epub 2024 Sep 23.
Abstract
Combined antiretroviral therapy has significantly reduced perinatal human immunodeficiency virus (HIV) transmission risk through breastfeeding, prompting shifts in clinical guidance to support breastfeeding for women with HIV who have sustained viral suppression. This review examines the current evidence on HIV transmission via breast milk, including risk factors, mechanisms, and risk reduction strategies to inform patient-centered and evidence-driven clinical care.
摘要
联合抗逆转录病毒疗法显著降低了通过母乳喂养传播围产期人类免疫缺陷病毒 (HIV) 的风险，促使临床指南转变为支持 HIV 感染妇女在病毒持续抑制的情况下进行母乳喂养。本文回顾了有关母乳传播 HIV 的现有证据，包括风险因素、机制和降低风险的策略，以为以患者为中心和以证据为基础的临床护理提供信息。
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