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人类免疫缺陷病毒与母乳喂养：在联合抗逆转录病毒疗法的现代时代，临床注意事项和传播机制。

Human Immunodeficiency Virus and Breastfeeding: Clinical Considerations and Mechanisms of Transmission in the Modern Era of Combined Antiretroviral Therapy.

机构信息

Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.

Earlham College, Richmond, IN 47374, USA.

出版信息

Clin Perinatol. 2024 Dec;51(4):783-799. doi: 10.1016/j.clp.2024.08.001. Epub 2024 Sep 23.

DOI:10.1016/j.clp.2024.08.001
PMID:39487020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11558571/
Abstract

Combined antiretroviral therapy has significantly reduced perinatal human immunodeficiency virus (HIV) transmission risk through breastfeeding, prompting shifts in clinical guidance to support breastfeeding for women with HIV who have sustained viral suppression. This review examines the current evidence on HIV transmission via breast milk, including risk factors, mechanisms, and risk reduction strategies to inform patient-centered and evidence-driven clinical care.

摘要

联合抗逆转录病毒疗法显著降低了通过母乳喂养传播围产期人类免疫缺陷病毒 (HIV) 的风险，促使临床指南转变为支持 HIV 感染妇女在病毒持续抑制的情况下进行母乳喂养。本文回顾了有关母乳传播 HIV 的现有证据，包括风险因素、机制和降低风险的策略，以为以患者为中心和以证据为基础的临床护理提供信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/11558571/c15d6fb60f32/nihms-2025410-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/11558571/724e987f6927/nihms-2025410-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/11558571/c15d6fb60f32/nihms-2025410-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/11558571/724e987f6927/nihms-2025410-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3327/11558571/c15d6fb60f32/nihms-2025410-f0002.jpg

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本文引用的文献

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From Guidelines to Practice: A Programmatic Model for Implementation of the Updated Infant Feeding Recommendations for People Living with HIV.从指南到实践：为感染艾滋病毒者实施最新婴儿喂养建议的计划模型
J Pediatric Infect Dis Soc. 2024 Jul 20;13(7):381-385. doi: 10.1093/jpids/piae045.
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Infant Feeding for Persons Living With and at Risk for HIV in the United States: Clinical Report.美国 HIV 感染者和 HIV 风险人群的婴儿喂养：临床报告。
Pediatrics. 2024 Jun 1;153(6). doi: 10.1542/peds.2024-066843.
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Guidelines and practice of breastfeeding in women living with HIV-Results from the European INSURE survey.
HIV 感染者母乳喂养指导和实践：欧洲 INSURE 调查结果。
HIV Med. 2024 Mar;25(3):391-397. doi: 10.1111/hiv.13583. Epub 2023 Nov 29.
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Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023.2023 年欧洲艾滋病临床学会指南 12.0 重大修订版。
HIV Med. 2023 Nov;24(11):1126-1136. doi: 10.1111/hiv.13542. Epub 2023 Oct 18.
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Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana.在博茨瓦纳，广泛中和抗体治疗可维持具有良好储存特征的儿童的 HIV 抑制。
Sci Transl Med. 2023 Jul 5;15(703):eadh0004. doi: 10.1126/scitranslmed.adh0004.
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Development and Implementation of an Interdisciplinary Model for the Management of Breastfeeding in Women With HIV in the United States: Experience From the Children's Hospital Colorado Immunodeficiency Program.在美国，建立并实施针对感染 HIV 的女性母乳喂养管理的跨学科模式：科罗拉多儿童医院免疫缺陷项目的经验。
J Acquir Immune Defic Syndr. 2023 Aug 15;93(5):395-402. doi: 10.1097/QAI.0000000000003213.
7
Breastfeeding Among People With Human Immunodeficiency Virus in North America: A Multisite Study.北美人类免疫缺陷病毒感染者母乳喂养状况的多中心研究
Clin Infect Dis. 2023 Nov 17;77(10):1416-1422. doi: 10.1093/cid/ciad235.
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Canadian Pediatric & Perinatal HIV/AIDS Research Group consensus recommendations for infant feeding in the HIV context.加拿大儿科与围产期艾滋病毒/艾滋病研究小组关于艾滋病毒背景下婴儿喂养的共识建议。
J Assoc Med Microbiol Infect Dis Can. 2023 Mar 1;8(1):7-17. doi: 10.3138/jammi-2022-11-03. eCollection 2023 Mar.
9
Successful implementation of new Swiss recommendations on breastfeeding of infants born to women living with HIV.瑞士关于感染艾滋病毒妇女所生婴儿母乳喂养的新建议成功实施。
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