The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Department of Anesthesiology, Shenzhen People's Hospital, The Second Clinical Medical College, The First Affiliated Hospital, Jinan University, Southern University of Science and Technology, Shenzhen, China.
BMC Public Health. 2024 Nov 1;24(1):3036. doi: 10.1186/s12889-024-20529-2.
Chronic headache (CH) is a widespread problem in clinical practice. The causes of the disease are very complex and varied, including organic, functional and even psychogenic causes. Adverse childhood experiences (ACEs) are related to several psychogenic neurological disorders. However, whether the number of ACEs is associated with the risk of developing CH has not been well established. Therefore, in this study, we aimed to identify the association between the number of ACEs and the risk of developing CH in the general population using a Chinese national survey.
Participants who reported experiencing headache in two consecutive waves of investigation from the China Health and Retirement Longitudinal Study (CHARLS) were defined as having CH and were included in this study. The life history information of the participants was then matched. Twelve types of ACEs were identified from the life history information. The participants were divided into four classes according to the number of ACEs. The association between the number of ACEs and the risk of developing CH was analysed using logistic regression.
A total of 654 (14.77%) of 4427 participants were defined as CH within 9 years of the survey. After adjusting for various confounding factors, compared to that associated with Class 1 (ACEs = 0), the OR for CH associated with Class 3 (ACEs = 2) was 1.68 (95% CI: 1.30-2.19), P < 0.001 and the OR for CH associated with Class 4 (ACEs > 2) was 2.62 (95% CI:2.04-3.38),P < 0.001. Further analysis of different types of ACEs demonstrated that physical abuse, household mental illness and five other types of ACEs were associated with the risk of developing CH.
Exposure to ACEs was associated with a greater risk of developing CH, indicating the importance of early intervention for individuals with ACEs to mitigate the detrimental impact of ACEs on CH and to promote health.
慢性头痛（CH）是临床实践中普遍存在的问题。该病的病因非常复杂和多样，包括器质性、功能性甚至心因性病因。不良的童年经历（ACEs）与多种心因性神经障碍有关。然而，ACEs 的数量是否与发生 CH 的风险相关尚未得到很好的证实。因此，在这项研究中，我们旨在使用中国全国性调查，确定 ACEs 的数量与普通人群发生 CH 的风险之间的关系。
从中国健康与退休纵向研究（CHARLS）的两次连续调查中报告头痛的参与者被定义为患有 CH，并被纳入本研究。然后对参与者的生活史信息进行匹配。从生活史信息中确定了 12 种 ACEs。根据 ACEs 的数量将参与者分为 4 类。使用逻辑回归分析 ACEs 的数量与发生 CH 的风险之间的关系。
在调查后的 9 年内，共有 654 名（14.77%）4427 名参与者被定义为 CH。在调整了各种混杂因素后，与 ACEs=0 的 Class 1 相比，ACEs=2 的 Class 3 发生 CH 的 OR 为 1.68（95%CI：1.30-2.19），P<0.001，ACEs>2 的 Class 4 发生 CH 的 OR 为 2.62（95%CI：2.04-3.38），P<0.001。对不同类型 ACEs 的进一步分析表明，身体虐待、家庭精神疾病和其他 5 种 ACEs 与发生 CH 的风险相关。
暴露于 ACEs 与发生 CH 的风险增加相关，表明对于 ACEs 的个体进行早期干预对于减轻 ACEs 对 CH 的不利影响和促进健康非常重要。
