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在资源有限的环境中,酒精唾液测试条与呼气酒精含量测定仪相比在创伤患者中的效用。

The utility of alcohol saliva test strips compared to the breathalyzer in trauma patients in a resource-limited setting.

作者信息

Davis Dylane N, Gondwe Jotham, An Selena J, Gallaher Jared, Charles Anthony

机构信息

Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA.

出版信息

World J Surg. 2024 Dec;48(12):3014-3019. doi: 10.1002/wjs.12384. Epub 2024 Nov 2.

Abstract

INTRODUCTION

The correlation between alcohol consumption and injury is undeniable. However, past research relying on self-reporting alcohol use likely resulted in underreporting and emphasizing the need to increase alcohol testing, especially in resource-limited settings where the burden of injuries is highest.

METHODS

This is a prospective analysis of injured patients presenting to the trauma center at Kamuzu Central Hospital in Lilongwe, Malawi. We collected information including patient age, sex, admission date, mechanism of injury, breathalyzer test and Rapid Response Alcohol Saliva Test Strips (AST) result, and survival.

RESULTS

A total of 805 trauma patients were included. The overall prevalence of alcohol consumption in this trauma cohort is 18.3%. There was a 95.5% agreement between the AST and breathalyzer test with a Kappa coefficient of 0.83. The sensitivity and specificity of the AST were determined to be 78.5% (CI 75.7-81.2) and 99.3% (CI 98.7-99.9), respectively. ROC analyses showed the AST to have excellent discrimination with an area under the curve of 0.88 (95% CI 0.85-0.92).

CONCLUSION

The prevalence of alcohol-related injury is high in Malawi and the use of the Alcohol Saliva Test Strips is feasible and correlated with results derived from the breathalyzer. Routine alcohol testing for trauma patients presenting to a resource-limited setting is imperative and should be implemented.

摘要

引言

饮酒与损伤之间的关联是不可否认的。然而,过去依赖自我报告饮酒情况的研究可能导致报告不足,并凸显了增加酒精检测的必要性,尤其是在损伤负担最重的资源有限环境中。

方法

这是一项对马拉维利隆圭卡穆祖中央医院创伤中心的受伤患者进行的前瞻性分析。我们收集了包括患者年龄、性别、入院日期、损伤机制、呼气酒精含量测试和快速反应酒精唾液测试条(AST)结果以及生存情况等信息。

结果

共纳入805例创伤患者。该创伤队列中饮酒的总体患病率为18.3%。AST与呼气酒精含量测试之间的一致性为95.5%,卡帕系数为0.83。AST的敏感性和特异性分别确定为78.5%(可信区间75.7 - 81.2)和99.3%(可信区间98.7 - 99.9)。ROC分析显示AST具有出色的区分能力,曲线下面积为0.88(95%可信区间0.85 - 0.92)。

结论

在马拉维,与酒精相关的损伤患病率很高,使用酒精唾液测试条是可行的,且与呼气酒精含量测试结果相关。对于前往资源有限环境的创伤患者进行常规酒精检测势在必行,应予以实施。

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