男性看电视、氧化应激与肾结石风险：一项对美国国家健康与营养检查调查（2011 - 2018年）数据进行中介分析的横断面研究

Television viewing, oxidative stress, and kidney stone risk in males: a cross-sectional study with mediation analysis of the NHANES data (2011-2018 years).

作者信息

Xu Zekun, Ma Min, Huang Ting, Lu Rihui, Jin Hangming, Fang Yinfei, Xu Min, Fang Yongjin

机构信息

Department of Urology Surgery, Jinhua Central Hospital, 365 Renmin Road, Jinhua, 321000, Zhejiang, People's Republic of China.

Jinhua Central Hospital, 365 Renmin Road, Jinhua, 321000, Zhejiang, People's Republic of China.

出版信息

Int Urol Nephrol. 2025 Mar;57(3):929-938. doi: 10.1007/s11255-024-04255-7. Epub 2024 Nov 2.

DOI:10.1007/s11255-024-04255-7

PMID:39487905

Abstract

PURPOSE

To explore the association between television viewing time (TV-hours) and dietary oxidative balance score (DOBS) with the kidney stone risk in males.

METHODS

We analyzed age, poverty to income ratio, race, education, hypertension, diabetes, smoke, alcohol use, triglycerides, TV-hours, and DOBS data in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. Multivariable logistic regression was uesd to evaluate the associations between TV-hours, lifestyle OBS (LOBS), DOBS, Total OBS (TOBS), and the risk of kidney stones. Interaction terms between subgroup measures were used to test for effect modification across subgroups. Mediation analysis was performed to explore the mediating effect of DOBS on the association between TV-hours and kidney stones. The restricted cubic spline (RCS) was applied to describe dose-response relationships between TV-hours and risk of kidney stones as well.

RESULTS

The study included 4167 males aged 20 and older, including 417 patients with kidney stones. The results showed that five or more TV-hours a day was associated with a higher risk of kidney stones [odds ratio (OR) = 1.16, (95% CI: 1.04-1.29), p = 0.01], and higher DOBS level was associated with a lower risk of kidney stones [OR = 0.97, (95% CI: 0.95-0.99), p = 0.004]. This association was remarkably consistent across TV-hours subgroups by age, race, alcohol use, hypertension and diabetes. According to the mediation analysis results, prolonged TV-hours is associated with an increased risk of kidney stones, this association is not mediated by DOBS. In other words, the impact of TV-hours on kidney stones risk is mainly a direct effect. When TV-hours is more than 2 hours, the odds ratio began to be greater than 1.

CONCLUSIONS

Overall, TV-hours was positively associated with kidney stones in males, whereas low DOBS was associated with kidney stones in males. This study suggests that an antioxidant diet and reduced television viewing time may be effective measures to prevent kidney stones in males.

摘要

目的

探讨男性看电视时间（电视时长）和饮食氧化平衡评分（DOBS）与肾结石风险之间的关联。

方法

我们分析了2011年至2018年美国国家健康与营养检查调查（NHANES）中的年龄、贫困与收入比、种族、教育程度、高血压、糖尿病、吸烟、饮酒、甘油三酯、电视时长和DOBS数据。采用多变量逻辑回归来评估电视时长、生活方式氧化平衡评分（LOBS）、DOBS、总氧化平衡评分（TOBS）与肾结石风险之间的关联。亚组测量之间的交互项用于检验亚组间的效应修正。进行中介分析以探讨DOBS在电视时长与肾结石关联中的中介作用。还应用受限立方样条（RCS）来描述电视时长与肾结石风险之间的剂量反应关系。

结果

该研究纳入了4167名20岁及以上的男性，其中包括417例肾结石患者。结果显示，每天看电视5小时或更长时间与较高的肾结石风险相关[比值比（OR）=1.16，（95%置信区间：1.04 - 1.29），p = 0.01]，而较高的DOBS水平与较低的肾结石风险相关[OR = 0.97，（95%置信区间：0.95 - 0.99），p = 0.004]。这种关联在按年龄、种族、饮酒情况、高血压和糖尿病划分的电视时长亚组中非常一致。根据中介分析结果，看电视时间延长与肾结石风险增加相关，这种关联不受DOBS介导。换句话说，电视时长对肾结石风险的影响主要是直接效应。当电视时长超过2小时时，比值比开始大于1。