Yin Guicao, Zhang Wentao, Zhang Jialong, Sheng Tao, Chen Binghai
Department of Urology, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhengjiang, 212000, Jiangsu Province, China.
Sci Rep. 2024 Dec 28;14(1):31075. doi: 10.1038/s41598-024-82075-6.
Previous studies have shown that diabetes is one of the risk factors for kidney stone formation. The Cardiometabolic Index (CMI) is a composite index used to assess an individual's cardiovascular health and metabolic status. CMI has been associated with several metabolic diseases. However, current evidence on the association between CMI and kidney stone risk is limited. The primary objective of this study was to investigate the association between CMI and kidney stones in US adults and to analyze whether diabetes mediates the association. Using data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and March 2018, this study examined the association between CMI and kidney stones incidence in US adults. Data were analyzed using a variety of statistical methods, including multifactorial logistic regression, subgroup analysis, restricted cubic spline curves (RCS), saturated threshold effects analysis, and mediated effects analysis. A total of 10,609 subjects were included in this study, of which 972 patients were diagnosed with kidney stones. The results of multifactorial logistic regression analysis after fully adjusting for confounding covariates showed a significant positive association between CMI and kidney stones, with an odds ratio (OR) of 1.29 and a 95% confidence interval (CI) of (1.16,1.44). In addition, there was a non-linear positive association between CMI and kidney stones. The results of mediation analysis showed that diabetes mellitus had a mediating role of 15.3% in the correlation between CMI and kidney stones. The findings of this study indicate that elevated CMI levels are associated with an increased risk of kidney stone formation, with diabetes playing a mediating role. These findings indicate that maintaining CMI within the lower range and addressing glycemic regulation is crucial for the prevention of kidney stones.
先前的研究表明，糖尿病是肾结石形成的危险因素之一。心脏代谢指数（CMI）是用于评估个体心血管健康和代谢状况的综合指数。CMI与多种代谢性疾病有关。然而，目前关于CMI与肾结石风险之间关联的证据有限。本研究的主要目的是调查美国成年人中CMI与肾结石之间的关联，并分析糖尿病是否介导了这种关联。利用2007年至2018年3月期间进行的美国国家健康与营养检查调查（NHANES）的数据，本研究考察了美国成年人中CMI与肾结石发病率之间的关联。使用了多种统计方法进行数据分析，包括多因素逻辑回归、亚组分析、受限立方样条曲线（RCS）、饱和阈值效应分析和中介效应分析。本研究共纳入10609名受试者，其中972例患者被诊断为肾结石。在对混杂协变量进行充分调整后的多因素逻辑回归分析结果显示，CMI与肾结石之间存在显著的正相关，比值比（OR）为1.29，95%置信区间（CI）为（1.16,1.44）。此外，CMI与肾结石之间存在非线性正相关。中介分析结果显示，糖尿病在CMI与肾结石之间的相关性中具有15.3%的中介作用。本研究结果表明，CMI水平升高与肾结石形成风险增加有关，糖尿病起中介作用。这些发现表明，将CMI维持在较低水平并控制血糖调节对于预防肾结石至关重要。
