Asikaer Aiminuer, Sun Cai, Shen Yan
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, PR, China.
Inflammopharmacology. 2025 Jan;33(1):183-194. doi: 10.1007/s10787-024-01587-9. Epub 2024 Nov 2.
Thiostrepton (TST) is a naturally occurring oligopeptide antibiotic with a demonstrated capacity to antagonize a broad spectrum of Gram-positive bacteria. It has been utilized as a safe antimicrobial agent in veterinary medicine. Despite its therapeutic potential, the clinical application of TST has been constrained by its poor solubility and bioavailability. However, an increasing number of studies indicate that TST possesses diverse pharmacological activities, including its significant role in microbe resistance and cancer countering. Notably, recent studies have pointed out that TST also possesses anti-inflammatory potential. It has exhibited promising therapeutic efficacy across various in vivo and in vitro disease models, including non-alcoholic fatty liver disease, inflammatory bowel disease, sepsis, psoriasis-like inflammation, and periodontitis. In this review, we describe the various pharmacological activities of TST, particularly its anti-inflammatory activity demonstrated in a variety of inflammatory diseases and the underlying mechanisms. These effects highlight the potential of TST as an anti-inflammatory agent for the treatment of inflammation diseases and for enhancing cellular therapies.
硫链丝菌素（TST）是一种天然存在的寡肽抗生素，具有拮抗多种革兰氏阳性菌的能力。它已在兽医学中用作安全的抗菌剂。尽管TST具有治疗潜力，但其临床应用受到其低溶解度和生物利用度的限制。然而，越来越多的研究表明，TST具有多种药理活性，包括其在微生物抗性和抗癌方面的重要作用。值得注意的是，最近的研究指出，TST还具有抗炎潜力。它在各种体内和体外疾病模型中均表现出有前景的治疗效果，包括非酒精性脂肪性肝病、炎症性肠病、败血症、银屑病样炎症和牙周炎。在这篇综述中，我们描述了TST的各种药理活性，特别是其在多种炎症性疾病中表现出的抗炎活性及其潜在机制。这些作用凸显了TST作为治疗炎症性疾病和增强细胞治疗的抗炎剂的潜力。
