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佛手柑精油诱导抗焦虑作用的神经回路。

A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.

作者信息

Zhu Meng-Yu, Dong Wan-Ying, Guo Jin-Rong, Huang Ji-Ye, Cheng Ping-Kai, Yang Yumeng, Liu An, Yang Xin-Lu, Zhu Xia, Zhang Zhi, Wang Yuanyin, Tao Wenjuan

机构信息

College & Hospital of Stomatology, Anhui Medical University, Key Lab of Oral Diseases Research of Anhui Province, Hefei, 230032, China.

Department of Physiology, Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.

出版信息

Adv Sci (Weinh). 2025 Jan;12(1):e2406766. doi: 10.1002/advs.202406766. Epub 2024 Nov 2.

DOI:10.1002/advs.202406766
PMID:39487959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11714174/
Abstract

Aromatic essential oils have been shown to relieve anxiety and enhance relaxation, although the neural circuits underlying these effects have remained unknown. Here, it is found that treatment with 1.0% bergamot essential oil (BEO) exerts anxiolytic-like effects through a neural circuit projecting from the anterior olfactory nucleus (AON) to the anterior cingulate cortex (ACC) in acute restraint stress model mice. Collectively, in vivo two-photon calcium imaging, viral tracing, and whole-cell patch clamp recordings show that inhalation exposure to 1.0% BEO can activate glutamatergic projections from the AON to GABAergic neurons in the ACC, which drives inhibition of local glutamatergic neurons (AON→ACC). Optogenetic or chemogenetic manipulation of this pathway can recapitulate or abolish the BEO-induced anxiolytic-like behavioral effects in mice with ARS. Beyond depicting a previously unrecognized pathway involved in stress response, this study provides a circuit mechanism for the effects of BEO and suggests a potential target for anxiety treatment.

摘要

芳香精油已被证明可以缓解焦虑并增强放松感，尽管这些作用背后的神经回路尚不清楚。在此，研究发现，在急性束缚应激模型小鼠中，用1.0%佛手柑精油（BEO）处理可通过从前嗅核（AON）投射到前扣带回皮质（ACC）的神经回路发挥抗焦虑样作用。总体而言，体内双光子钙成像、病毒示踪和全细胞膜片钳记录表明，吸入1.0% BEO可激活从AON到ACC中GABA能神经元的谷氨酸能投射，从而驱动对局部谷氨酸能神经元的抑制（AON→ACC）。对该通路进行光遗传学或化学遗传学操作可以重现或消除BEO在急性束缚应激（ARS）小鼠中诱导的抗焦虑样行为效应。除了描绘出一条先前未被认识的参与应激反应的通路外，本研究还提供了BEO作用的回路机制，并提示了一个潜在的焦虑治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/7348ea660b35/ADVS-12-2406766-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/ceafa93ccf23/ADVS-12-2406766-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/779a5473b636/ADVS-12-2406766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/7f9b96e3fc96/ADVS-12-2406766-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/58371a078a8f/ADVS-12-2406766-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/6b90831b5e37/ADVS-12-2406766-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/7348ea660b35/ADVS-12-2406766-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/ceafa93ccf23/ADVS-12-2406766-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/779a5473b636/ADVS-12-2406766-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/7f9b96e3fc96/ADVS-12-2406766-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/58371a078a8f/ADVS-12-2406766-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/6b90831b5e37/ADVS-12-2406766-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5d2/11714174/7348ea660b35/ADVS-12-2406766-g003.jpg

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