Preclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, 87036 Rende, Italy.
Department of Physiology and Anatomy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Int J Mol Sci. 2020 Apr 9;21(7):2597. doi: 10.3390/ijms21072597.
The essential oil obtained by the fresh fruit of Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.
由里索和波托的新鲜果实获得的精油在全球范围内被用于芳香疗法，以减轻疼痛、促进睡眠诱导和/或减轻应激引起的焦虑的影响。临床前药理学数据表明，佛手柑精油（BEO）调节特定的神经递质传递，并显示出一种不同于苯并二氮䓬类药物地西泮的抗焦虑松弛作用，这表明除 GABA 能外，其他神经递质传递可能也参与其中。一些关于精油的研究表明，5-羟色胺（5-HT）能神经传递在焦虑中起作用。有趣的是，在 5-羟色胺受体中，5-HT1A 亚型似乎在控制焦虑中起着关键作用。在这里，我们报告说，5-HT1A 受体的调制通过选择性激动剂（(±)8-OH-DPAT）或拮抗剂（WAY-100635）可能会影响 BEO 在开阔场和高架十字迷宫测试中的一些抗焦虑松弛作用。
