Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genetics, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
School of Public Health, Chengdu Medical College, Chengdu, Sichuan, 610500, China.
Heart Lung. 2025 Jan-Feb;69:192-201. doi: 10.1016/j.hrtlng.2024.10.012. Epub 2024 Nov 1.
Unhealthy sleep patterns and accelerated biological age are frequently associated with multiple chronic respiratory diseases (CRDs), including COPD, asthma, and interstitial lung disease (ILD). However, few studies have explored the role of biological age in the relationship between sleep patterns and CRDs.
To explore the association between sleep patterns and CRD, and the extent to which biological age mediates the relationship between sleep patterns and CRD.
This was a prospective cohort study based on UK Biobank. The sleep score was derived from five self-reported sleep traits: sleep duration, daytime sleepiness, chronotype, snoring, and insomnia. The score ranged from 0 (least healthy) to 5 (healthiest). Biological age was represented by PhenoAgeAccel.
Among 303,588 participants, 11,105 (3.7 %), 9,380 (3.1 %), and 1,667 (0.5 %) were diagnosed with asthma, COPD, and ILD, respectively. Each 1-point increase in the sleep score was associated with a 0.156-year reduction in PhenoAgeAccel, and 14.3 %, 12.4 %, and 6.7 % reduction in asthma, COPD, and ILD, respectively. For each 1-year increase in PhenoAgeAccel, the risk of asthma, COPD, and ILD increased by 2.8 %, 4.3 %, and 5.7 %, respectively. PhenoAgeAccel mediated the associations between the sleep score and asthma, COPD, and ILD, with a mediated proportion (95 % CI) of 2.81 % (2.35 % to 3.27 %), 4.94 % (4.23 % to 5.66 %), and 12.48 % (10.43 % to 14.53 %), respectively.
A better sleep score was significantly associated with younger biological age and decreased risk of CRDs, with biological age playing a mediating role in the association between sleep score and CRDs.
不健康的睡眠模式和加速的生物年龄经常与多种慢性呼吸道疾病（CRD）相关，包括 COPD、哮喘和间质性肺疾病（ILD）。然而，很少有研究探讨生物年龄在睡眠模式与 CRD 之间的关系中的作用。
探讨睡眠模式与 CRD 的关系，以及生物年龄在睡眠模式与 CRD 之间的关系中起多大程度的中介作用。
这是一项基于英国生物库的前瞻性队列研究。睡眠评分来自五个自我报告的睡眠特征：睡眠时间、白天嗜睡、昼夜节律、打鼾和失眠。评分范围从 0（最不健康）到 5（最健康）。生物年龄由 PhenoAgeAccel 表示。
在 303588 名参与者中，分别有 11105（3.7%）、9380（3.1%）和 1667（0.5%）被诊断为哮喘、COPD 和 ILD。睡眠评分每增加 1 分，PhenoAgeAccel 就会减少 0.156 岁，哮喘、COPD 和 ILD 分别减少 14.3%、12.4%和 6.7%。PhenoAgeAccel 每增加 1 岁，哮喘、COPD 和 ILD 的风险分别增加 2.8%、4.3%和 5.7%。PhenoAgeAccel 介导了睡眠评分与哮喘、COPD 和 ILD 之间的关联，其介导比例（95%CI）分别为 2.81%（2.35%至 3.27%）、4.94%（4.23%至 5.66%）和 12.48%（10.43%至 14.53%）。
更好的睡眠评分与更年轻的生物年龄和降低的 CRD 风险显著相关，生物年龄在睡眠评分与 CRD 之间的关联中起中介作用。
