General Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
PLoS One. 2024 Sep 6;19(9):e0309870. doi: 10.1371/journal.pone.0309870. eCollection 2024.
Although healthy sleep patterns have been linked to a lower risk of cardiovascular disease in earlier research, it is unclear how beneficial they are for venous thromboembolism (VTE).
This research aimed to examine the correlation between sleep patterns, genetic susceptibility, and VTE.
In the UK Biobank cohort, healthy sleep behaviors were defined as early chronotype, 7-8 hours of sleep each day, no snoring, infrequent insomnia, and infrequent daytime sleepiness. Each of the five criteria was given 1 point, creating a healthy sleep score ranging from 0 to 5. Cox proportional hazards regression models were utilized to examine the associations between genetic susceptibility, healthy sleep score and VTE.
The UK Biobank study included 384,758 participants aged 56.6 ± 8.0 years. After a median of 11.9 years of follow-up, 8,885 (2.3%) participants were diagnosed with VTE. A healthy sleep score inversely affected VTE risk. For participants with a score of 5, the hazard ratio of VTE was 0.813 (95% confidence interval: 0.758-0.873, P<0.001) compared to those with a score ≤2. Early chronotype, sleeping 7-8 hours each day, infrequent insomnia, and infrequent daytime sleepiness were significantly associated with a 7.9%, 8.3%, 5.1%, and 20.7% lower risk of VTE, respectively. In addition, the correlation between sleep pattern and the incidence of VTE was consistent, regardless of genetic susceptibility (P for interaction = 0.366).
Our secondary analysis of a large-scale prospectively gathered registry revealed that individuals with a healthy sleep pattern are significantly correlated with lower risk of developing VTE, irrespective of genetic susceptibility.
尽管早期研究表明健康的睡眠模式与心血管疾病风险降低有关，但目前尚不清楚其对静脉血栓栓塞症（VTE）的益处有多大。
本研究旨在探讨睡眠模式、遗传易感性与 VTE 之间的相关性。
在英国生物库队列中，健康的睡眠行为定义为早睡型、每天 7-8 小时的睡眠时间、不打鼾、不频繁失眠和不频繁白天嗜睡。每个标准得 1 分，健康睡眠评分范围为 0 至 5 分。利用 Cox 比例风险回归模型来检验遗传易感性、健康睡眠评分与 VTE 之间的关联。
英国生物库研究纳入了 384758 名年龄为 56.6±8.0 岁的参与者。中位随访 11.9 年后，8885（2.3%）名参与者被诊断为 VTE。健康睡眠评分与 VTE 风险呈负相关。对于评分 5 分的参与者，VTE 的风险比为 0.813（95%置信区间：0.758-0.873，P<0.001），与评分≤2 分的参与者相比。早睡型、每天睡 7-8 小时、不频繁失眠和不频繁白天嗜睡分别与 VTE 风险降低 7.9%、8.3%、5.1%和 20.7%显著相关。此外，无论遗传易感性如何，睡眠模式与 VTE 发生率之间的相关性是一致的（P 交互=0.366）。
我们对一项大规模前瞻性注册研究进行的二次分析表明，具有健康睡眠模式的个体与较低的 VTE 发病风险显著相关，而与遗传易感性无关。
