神经周围浸润与喉鳞状细胞癌：一项系统综述
Perineural invasion and laryngeal squamous cell carcinoma: a systematic review.
作者信息
Quintana Debora Modelli Vianna Ocampo, Dedivitis Rogerio Aparecido, Kowalski Luiz Paulo
机构信息
Hospital Heliópolis, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.
Hospital Das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.
出版信息
Braz J Otorhinolaryngol. 2025 Jan-Feb;91(1):101519. doi: 10.1016/j.bjorl.2024.101519. Epub 2024 Nov 1.
OBJECTIVES
Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer.
METHODS
A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis.
RESULTS
A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59‒0.86); disease-free survival RR 0.51 (0.14-1.95); and locoregional recurrence RR 1.71 (1.25-2.35).
CONCLUSION
IPN is a negative prognostic factor in laryngeal cancer.
目的
多项研究评估了神经周围浸润（IPN）在喉癌中的预后意义；然而，结果尚无定论。因此，我们进行了一项荟萃分析，旨在确定IPN在喉癌中的预后价值。
方法
进行文献综述，通过PubMed、Scielo、Lilacs、Cochrane和Websco检索MedLine。使用RevMan 5.4进行统计分析。
结果
共纳入19项喉癌研究。结果表明，喉癌中的IPN显示2年生存率的风险比（RR）为0.71（0.59 - 0.86）；无病生存率RR为0.51（0.14 - 1.95）；局部区域复发RR为1.71（1.25 - 2.35）。
结论
IPN是喉癌的一个负性预后因素。
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