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神经周围浸润与喉鳞状细胞癌：一项系统综述

Perineural invasion and laryngeal squamous cell carcinoma: a systematic review.

作者信息

Quintana Debora Modelli Vianna Ocampo, Dedivitis Rogerio Aparecido, Kowalski Luiz Paulo

机构信息

Hospital Heliópolis, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.

Hospital Das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.

出版信息

Braz J Otorhinolaryngol. 2025 Jan-Feb;91(1):101519. doi: 10.1016/j.bjorl.2024.101519. Epub 2024 Nov 1.

DOI:10.1016/j.bjorl.2024.101519
PMID:39488177
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11565387/
Abstract

OBJECTIVES

Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer.

METHODS

A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis.

RESULTS

A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59‒0.86); disease-free survival RR 0.51 (0.14-1.95); and locoregional recurrence RR 1.71 (1.25-2.35).

CONCLUSION

IPN is a negative prognostic factor in laryngeal cancer.

摘要

目的

多项研究评估了神经周围浸润（IPN）在喉癌中的预后意义；然而，结果尚无定论。因此，我们进行了一项荟萃分析，旨在确定IPN在喉癌中的预后价值。

方法

进行文献综述，通过PubMed、Scielo、Lilacs、Cochrane和Websco检索MedLine。使用RevMan 5.4进行统计分析。

结果

共纳入19项喉癌研究。结果表明，喉癌中的IPN显示2年生存率的风险比（RR）为0.71（0.59 - 0.86）；无病生存率RR为0.51（0.14 - 1.95）；局部区域复发RR为1.71（1.25 - 2.35）。

结论

IPN是喉癌的一个负性预后因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/60dc8ebd2095/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/a7281effc584/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/f1531a009acd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/521acda401aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/5f470624a599/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/29e030fc499f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/c11c392c76dc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/60dc8ebd2095/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/a7281effc584/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/f1531a009acd/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/521acda401aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/5f470624a599/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/29e030fc499f/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/c11c392c76dc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f47/11565387/60dc8ebd2095/gr7.jpg

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本文引用的文献

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J Voice. 2023 Oct 25. doi: 10.1016/j.jvoice.2023.09.008.
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Perineural Invasion Predicts Local Recurrence and Poor Survival in Laryngeal Cancer.神经周围浸润预示喉癌局部复发及预后不良。
J Clin Med. 2023 Jan 5;12(2):449. doi: 10.3390/jcm12020449.
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口腔鳞状细胞癌中神经侵犯的分子和细胞机制：治疗干预的潜在靶点
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Evaluating Laryngopharyngeal Tumor Extension Using Narrow Band Imaging Versus Conventional White Light Imaging.使用窄带成像与常规白光成像评估喉咽肿瘤的扩展。
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