Welty T E, Robinson F C, Mayer P R
Epilepsia. 1986 Jan-Feb;27(1):76-80. doi: 10.1111/j.1528-1157.1986.tb03504.x.
In an attempt to evaluate the accuracy of phenytoin (PHT) pharmacokinetic dosage adjustments in a private practice setting, three single dose-concentration pair methods and three multiple point PHT pharmacokinetic dosing methods were studied. Dose and concentration data from 28 patients seen in a private neurology practice were utilized for the study. From a comparison of these methods in private practice seizure patients, it appears that the Bayesian feedback method may be the most accurate in making routine PHT dosage adjustments, perhaps by minimizing the contribution of unknown variables within the Bayesian approach.
为了评估在私人诊所环境中苯妥英（PHT）药代动力学剂量调整的准确性，研究了三种单剂量 - 浓度对方法和三种多点PHT药代动力学给药方法。本研究使用了在一家私人神经科诊所就诊的28名患者的剂量和浓度数据。从这些方法在私人诊所癫痫患者中的比较来看，贝叶斯反馈方法在进行常规PHT剂量调整时可能是最准确的，这可能是通过在贝叶斯方法中最小化未知变量的影响来实现的。
