Kojima Gotaro, Taniguchi Yu, Aoyama Reijiro, Urano Tomohiko
Department of Research, CLINIC 9ru, Tokyo, Japan.
Health and Environmental Risk Division, National Institute for Environmental Studies, Ibaraki, Japan.
J Am Med Dir Assoc. 2025 Jan;26(1):105328. doi: 10.1016/j.jamda.2024.105328. Epub 2024 Oct 30.
To examine the associations of smoking cessation with the subsequent frailty status trajectory using data from a nationally representative sample of community-dwelling older adults living in England.
A prospective panel study.
A total of 2600 community-dwelling older adults aged 60 or older in England who used to smoke.
The past smokers were divided into 5 groups based on years since smoking cessation: 0-10, 11-20, 21-30, 31-40, and 41+ years. The Frailty Index (FI) was constructed using 60 deficits and repeatedly calculated every 2 years over 16 years. Trajectories of FI according to years since smoking cessation were estimated by a mixed-effects model.
A mixed-effects model adjusted for age, sex, education, wealth, and alcohol use showed that FI increased over time in all groups and that longer duration since smoking cessation was significantly associated with lower FI (more fit). Those who quit 41 years earlier or more had the lowest frailty trajectory, however, there was still a gap between them and never smokers.
The current study showed that past smokers with a longer duration of quitting smoking had a significantly lower degree of frailty at baseline and over time. These findings highlight beneficial effects of smoking cessation on frailty even in middle or old age and could be used in public health education to promote the importance of quitting smoking.
利用来自英国具有全国代表性的社区居住老年人样本数据,研究戒烟与随后的衰弱状态轨迹之间的关联。
一项前瞻性队列研究。
共有2600名居住在英国、年龄在60岁及以上且曾经吸烟的社区居住老年人。
过去吸烟者根据戒烟年限分为5组:0 - 10年、11 - 20年、21 - 30年、31 - 40年和41年及以上。衰弱指数(FI)使用60项缺陷构建,并在16年中每2年重复计算一次。根据戒烟年限估计FI的轨迹,采用混合效应模型。
一个根据年龄、性别、教育程度、财富和饮酒情况进行调整的混合效应模型显示,所有组的FI随时间增加,且戒烟时间越长与FI越低(身体越健康)显著相关。那些在41年或更早以前戒烟的人衰弱轨迹最低,然而,他们与从不吸烟者之间仍存在差距。
当前研究表明,戒烟时间较长的既往吸烟者在基线和随访期间衰弱程度显著较低。这些发现凸显了即使在中年或老年,戒烟对衰弱的有益影响,可用于公共健康教育以促进戒烟的重要性。