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声遗传学在慢性病治疗中的应用：一种细胞调控的新方法。

Sonogenetics in the Treatment of Chronic Diseases: A New Method for Cell Regulation.

作者信息

Zhu Mingrui, Fang Yan, Sun Yikang, Li Shaoyue, Yu Jifeng, Xiong Bing, Wen Congjian, Zhou Boyang, Huang Bin, Yin Haohao, Xu Huixiong

机构信息

Department of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China.

Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.

出版信息

Adv Sci (Weinh). 2024 Dec;11(48):e2407373. doi: 10.1002/advs.202407373. Epub 2024 Nov 3.

DOI:10.1002/advs.202407373
PMID:39488795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11672274/
Abstract

Sonogenetics is an innovative technology that integrates ultrasound with genetic editing to precisely modulate cellular activities in a non-invasive manner. This method entails introducing and activating mechanosensitive channels on the cell membrane of specific cells using gene delivery vectors. When exposed to ultrasound, these channels can be manipulated to open or close, thereby impacting cellular functions. Sonogenetics is currently being used extensively in the treatment of various chronic diseases, including Parkinson's disease, vision restoration, and cancer therapy. This paper provides a comprehensive review of key components of sonogenetics and focuses on evaluating its prospects and potential challenges in the treatment of chronic disease.

摘要

声遗传学是一项创新技术，它将超声波与基因编辑相结合，以非侵入性方式精确调节细胞活动。该方法需要使用基因传递载体在特定细胞的细胞膜上引入并激活机械敏感通道。当暴露于超声波时，这些通道可以被操控打开或关闭，从而影响细胞功能。声遗传学目前正广泛应用于各种慢性疾病的治疗，包括帕金森病、视力恢复和癌症治疗。本文对声遗传学的关键组成部分进行了全面综述，并着重评估其在慢性疾病治疗中的前景和潜在挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/256740810338/ADVS-11-2407373-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/1ea235e48609/ADVS-11-2407373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/bf98e0d3f741/ADVS-11-2407373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/d32751ba6b8b/ADVS-11-2407373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/45152b21ee7f/ADVS-11-2407373-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/6908455a2dde/ADVS-11-2407373-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/801fd7afa7bd/ADVS-11-2407373-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/54d9154ab531/ADVS-11-2407373-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/b649834022cb/ADVS-11-2407373-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/e4f7d656b041/ADVS-11-2407373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/e2cc0b4e959a/ADVS-11-2407373-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/ac20ce195149/ADVS-11-2407373-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/74b804853497/ADVS-11-2407373-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/256740810338/ADVS-11-2407373-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/1ea235e48609/ADVS-11-2407373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/bf98e0d3f741/ADVS-11-2407373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/d32751ba6b8b/ADVS-11-2407373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/45152b21ee7f/ADVS-11-2407373-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/6908455a2dde/ADVS-11-2407373-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/801fd7afa7bd/ADVS-11-2407373-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/54d9154ab531/ADVS-11-2407373-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/b649834022cb/ADVS-11-2407373-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/e4f7d656b041/ADVS-11-2407373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/e2cc0b4e959a/ADVS-11-2407373-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/ac20ce195149/ADVS-11-2407373-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/74b804853497/ADVS-11-2407373-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ee9/11672274/256740810338/ADVS-11-2407373-g013.jpg

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In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits.

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[2]
Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration.

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[3]
Sonogenetics for Monitoring and Modulating Biomolecular Function by Ultrasound.

Angew Chem Int Ed Engl. 2024-3-22

[4]
Optogenetics for light control of biological systems.

Nat Rev Methods Primers. 2022

[5]
Tuning of cellular insulin release by music for real-time diabetes control.

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[6]
A TRPV4 mutation caused Charcot-Marie-Tooth disease type 2C with scapuloperoneal muscular atrophy overlap syndrome and scapuloperoneal spinal muscular atrophy in one family: a case report and literature review.

BMC Neurol. 2023-6-30

[7]
Artificial intelligence-assisted ultrasound image analysis to discriminate early breast cancer in Chinese population: a retrospective, multicentre, cohort study.

EClinicalMedicine. 2023-5-25

[8]
Modulation of deep neural circuits with sonogenetics.

Proc Natl Acad Sci U S A. 2023-5-30

[9]
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.

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[10]
The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation.

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