Demirlek Cemal, Verim Burcu, Zorlu Nabi, Demir Muhammed, Yalincetin Berna, Eyuboglu Merve S, Cesim Ezgi, Uzman-Özbek Simge, Süt Ekin, Öngür Dost, Bora Emre
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
Psychiatry Res. 2024 Dec;342:116251. doi: 10.1016/j.psychres.2024.116251. Epub 2024 Oct 28.
Abnormal connectivity in the brain has been linked to the pathophysiology of severe mental illnesses, including bipolar disorder and schizophrenia. The current study aimed to investigate large-scale functional networks and global network metrics in clinical high-risk for bipolardisorder (CHR-BD, n = 25), clinical high-risk for psychosis (CHR-P, n = 30), and healthy controls (HCs, n = 19). Help-seeking youth at CHR-BD and CHR-P were recruited from the early intervention program at Dokuz Eylul University, Izmir, Turkey. Resting-state functional magnetic resonance imaging scans were obtained from youth at CHR-BD, CHR-P, and HCs. Graph theoretical analysis and network-based statistics were employed to construct and examine the topological features of the whole-brain metrics and large-scale functional networks. Connectivity was increased (i) between the visual and default mode, (ii) between the visual and salience, (iii) between the visual and cingulo-opercular networks, and decreased (i) within the default mode and (ii) between the default mode and fronto-parietal networks in the CHR-P compared to HCs. Decreased global efficiency was found in CHR-P compared to CHR-BD. Functional networks were not different between CHR-BD and HCs. Global efficiency was negatively correlated with subthreshold positive symptoms and thought disorder in the high-risk groups. The current results suggest disrupted networks in CHR-P compared to HCs and CHR-BD. Moreover, transdiagnostic psychosis features are linked to functional brain networks in the at-risk groups. However, given the small, medicated sample, results are exploratory and hypothesis-generating.
大脑中的异常连接已与严重精神疾病的病理生理学相关联，包括双相情感障碍和精神分裂症。当前研究旨在调查双相情感障碍临床高危人群（CHR-BD，n = 25）、精神病临床高危人群（CHR-P，n = 30）和健康对照者（HCs，n = 19）的大规模功能网络和全局网络指标。CHR-BD和CHR-P中寻求帮助的青少年是从土耳其伊兹密尔多库兹艾吕尔大学的早期干预项目中招募的。对CHR-BD、CHR-P的青少年以及HCs进行了静息态功能磁共振成像扫描。采用图论分析和基于网络的统计方法来构建和检查全脑指标和大规模功能网络的拓扑特征。与HCs相比，CHR-P中（i）视觉和默认模式之间、（ii）视觉和突显网络之间、（iii）视觉和扣带-脑岛网络之间的连接性增加，而（i）默认模式内以及（ii）默认模式和额顶网络之间的连接性降低。与CHR-BD相比，CHR-P中全局效率降低。CHR-BD和HCs之间的功能网络没有差异。高危组中全局效率与阈下阳性症状和思维障碍呈负相关。当前结果表明，与HCs和CHR-BD相比，CHR-P中的网络受到破坏。此外，跨诊断精神病特征与高危组的功能性脑网络相关。然而，鉴于样本量小且有用药情况，结果具有探索性且仅供生成假设。
