Life Sciences Institute, Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, Guangxi, 530021, PR China; Taizhou Key Laboratory of Medical Devices and Advanced Materials, Research Institute of Zhejiang University, Taizhou, 318000, PR China.
Taizhou Key Laboratory of Medical Devices and Advanced Materials, Research Institute of Zhejiang University, Taizhou, 318000, PR China; Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, PR China.
Biosens Bioelectron. 2025 Jan 15;268:116860. doi: 10.1016/j.bios.2024.116860. Epub 2024 Oct 25.
Chronic wounds cause serious health and economic burdens on patients and society. Herein, a wireless and flexible smart wound dressing was developed for matrix metalloproteinase-9 (MMP-9) monitoring and antimicrobial treatment toward chronic wound management. The highly sensitive radio frequency MMP-9 sensor was realized based on a bioresponsive hydrogel with the bioactive peptide sequences. Taking advantage of the flexible inductive-capacitive (LC) circuit and bioresponsive hydrogel, the wireless and wearable smart wound dressing offered an efficient strategy for in-situ wound analysis. Besides, the controlled release of silver nanoparticles (AgNPs) from the degradable hydrogel exhibited significant antimicrobial efficacy against typical bacteria in wound infection including Escherichia coli and Staphylococcus aureus. The analysis of MMP-9 in wound exudate from diabetic foot ulcer (DFU) patients demonstrated good accuracy cross-validated with gold-standard fluorescent measurements, providing great potential for personalized wound management.
慢性伤口给患者和社会带来了严重的健康和经济负担。在此，我们开发了一种无线且灵活的智能伤口敷料，用于监测基质金属蛋白酶-9（MMP-9）并进行抗菌治疗以管理慢性伤口。基于具有生物活性肽序列的响应性水凝胶实现了高度灵敏的射频 MMP-9 传感器。利用灵活的感应式电容（LC）电路和响应性水凝胶，无线且可穿戴的智能伤口敷料为原位伤口分析提供了有效的策略。此外，银纳米粒子（AgNPs）从可降解水凝胶中的受控释放对伤口感染中的典型细菌（包括大肠杆菌和金黄色葡萄球菌）表现出显著的抗菌功效。对糖尿病足溃疡（DFU）患者伤口渗液中 MMP-9 的分析与金标准荧光测量结果具有良好的准确性，为个性化伤口管理提供了巨大的潜力。
